Results 31 to 40 of about 37,032,341 (244)

Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist. [PDF]

ACS Chem Neurosci, 2022
Human trace amine-associated receptor subtype 1 (hTAAR1) is a G protein-coupled receptor that has therapeutic potential for multiple diseases, including schizophrenia, drug addiction, and Parkinson's disease (PD). Although several potent agonists have been identified and have shown positive results in various clinical trials for schizophrenia, the ...
Decker AM, Brackeen MF, Mohammadkhani A, Kormos CM, Hesk D, Borgland SL, Blough BE.   +6 more
europepmc   +3 more sources

Robust aversive effects of trace amine-associated receptor 1 activation in mice. [PDF]

Neuropsychopharmacology, 2023
Drugs that stimulate the trace amine-associated receptor 1 (TAAR1) are under clinical investigation as treatments for several neuropsychiatric disorders. Previous studies in a genetic mouse model of voluntary methamphetamine intake identified TAAR1, expressed by the Taar1 gene, as a critical mediator of aversive methamphetamine effects. Methamphetamine
Shabani S, Houlton S, Ghimire B, Tonello D, Reed C, Baba H, Aldrich S, Phillips TJ.   +7 more
europepmc   +3 more sources

Trace amine receptor in GtoPdb v.2023.1 [PDF]

, 2023
Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families.
Anthony P. Davenport, Maguire, Janet J., Parker, William A.E., Tom I. Bonner, Davenport, Anthony P., Bonner, Tom I., Foord, Stephen M., Stephen M. Foord, Janet J. Maguire, William A.E. Parker   +9 more
core   +1 more source

Trace amine-associated receptor 1 as a monoaminergic modulator in brain [PDF]

Biochemical Pharmacology, 2009
Brain monoaminergic systems play critical roles in mood, cognition, emotion, reward, learning and attention, and aberrance in brain monoaminergic activity is associated with a variety of neuropsychiatric disorders/diseases. The present commentary focuses on trace amine-associated receptor 1 (TAAR1) and its potential regulatory roles in brain ...
Zhihua, Xie, Gregory M, Miller
openaire   +2 more sources

Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer. [PDF]

Int J Mol Sci, 2021
Trace amine-associated receptor 1 (TAAR1) is a Gαs- protein coupled receptor that plays an important role in the regulation of the immune system and neurotransmission in the CNS. In ovarian cancer cell lines, stimulation of TAAR1 via 3-iodothyronamine (T1AM) reduces cell viability and induces cell death and DNA damage. Aim of this study was to evaluate
Vogelsang TLR, Vattai A, Schmoeckel E, Kaltofen T, Chelariu-Raicu A, Zheng M, Mahner S, Mayr D, Jeschke U, Trillsch F.   +9 more
europepmc   +5 more sources

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes [PDF]

Journal of Neuroimmune Pharmacology, 2011
Although most research to date on Trace Amine Associated Receptor 1 (TAAR1) has focused on its role in the brain, it has been recognized since its discovery in 2001 that TAAR1 mRNA is expressed in peripheral tissues as well, suggesting that this receptor may play a role in non-neurological pathways.
Michael W, Panas, Zhihua, Xie, Helen N, Panas, Marius C, Hoener, Eric J, Vallender, Gregory M, Miller   +5 more
openaire   +2 more sources

Trace amine-associated receptor 1 (TAAR1) agonists

Archives of Psychiatry Research, 2022
Overview of current developments about trace amine- associated receptor 1 (TAAR1 ...
Peitl, Vjekoslav, Vlahović, Darko
openaire   +3 more sources

Role of Glial Trace Amine Associated Receptor 1 (TAAR1) and Microbiota in Schizophrenia. [PDF]

Neurochem Res
Trace amine-associated receptors (TAARs) are a class of G protein-coupled receptors that respond to metabolic derivatives of the amino acids such as phenylalanine, tyrosine, and tryptophan. Trace amines derive their name from the fact that their concentration in the periphery as well as in the central nervous system (CNS) is in trace amounts compared ...
Tsytsarev V, Vaganova AN, Volnova A, Fesenko Z, Getachew B, Gainetdinov RR, Tizabi Y.   +6 more
europepmc   +3 more sources

Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics [PDF]

Biological Psychiatry, 2017
Narcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepiness and cataplexy, a loss of muscle tone triggered by emotional stimulation. Current narcolepsy pharmacotherapeutics include controlled substances with abuse potential or drugs with undesirable side effects.
Sarah W, Black, Michael D, Schwartz, Tsui-Ming, Chen, Marius C, Hoener, Thomas S, Kilduff   +4 more
openaire   +2 more sources

Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1). [PDF]

Cell Mol Neurobiol, 2020
Trace amines and their primary receptor, Trace Amine-Associated Receptor-1 (TAAR1) are widely studied for their involvement in the pathogenesis of neuropsychiatric disorders despite being found in the gastrointestinal tract at physiological levels.
Bugda Gwilt K, González DP, Olliffe N, Oller H, Hoffing R, Puzan M, El Aidy S, Miller GM.   +7 more
europepmc   +3 more sources