Results 41 to 50 of about 37,032,341 (244)

Biological evaluation and in silico studies of novel compounds as potent TAAR1 agonists that could be used in schizophrenia treatment

Frontiers in Pharmacology, 2023
Introduction: Schizophrenia is a serious mental illness that requires effective treatment with minimal adverse effects. As preclinical and clinical research progresses, trace amine-associated receptor 1 (TAAR1) is becoming a potential new target for the ...
Yunjie Wang, Zhaofeng Liu, Jing Lu, Wenyan Wang, Lin Wang, Yifei Yang, Hongbo Wang, Liang Ye, Jianzhao Zhang, Jingwei Tian   +9 more
doaj   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Incretin-like effects of small molecule trace amine-associated receptor 1 agonists

Molecular Metabolism, 2016
Objective: Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies.
Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Basil Künnecke, Christoph Ullmer, Hugues Matile, Marc Bedoucha, Roger D. Norcross, Nickki Ottaway-Parker, Diego Perez-Tilve, Karin Conde Knape, Matthias H. Tschöp, Marius C. Hoener, Sabine Sewing   +15 more
doaj   +1 more source

Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites [PDF]

Bioorganic & Medicinal Chemistry Letters, 2008
Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines.
Aaron N, Snead, Motonori, Miyakawa, Edwin S, Tan, Thomas S, Scanlan   +3 more
openaire   +2 more sources

The Role of Trace Amine-Associated Receptor 1 (TAAR1) in the Pathophysiology and Treatment of Depression. [PDF]

Curr Neuropharmacol
Depression is a chronic and recurrent psychiatric condition believed to result from an interaction between genetic susceptibility and environmental stimuli. Although current therapies prescribed for depression can be effective, it will take several weeks to demonstrate their full effectiveness and is often ...
Guan W.
europepmc   +3 more sources

Psychosocial Stress Induces Orofacial Mechanical Allodynia Due to the Enhancement of Transient Receptor Potential Ankyrin 1 Expression in Trigeminal Ganglion Neurons via the Increment of the Trace Amine-Associated Receptor 7f Expression

Stresses, 2022
(1) Background: Chronic psychosocial stress can lead to oral dysesthesia with tongue pain. We examined whether psychosocial stress causes orofacial pain, and analyzed the comprehensive gene expression patterns of circulating cells and transient receptor ...
Ko Ito, Masamichi Shinoda, Kumi Soma, Daisuke Ikutame, Eiji Ikami, Yosuke Mizuno, Michihiko Usui, Seiji Asoda, Tsuyoshi Sato   +8 more
doaj   +1 more source

Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity [PDF]

NeuroToxicology, 2017
Trace amine-associated receptor 1 (TAAR1) is activated by methamphetamine (MA) and modulates dopaminergic (DA) function. Although DA dysregulation is the hallmark of MA-induced neurotoxicity leading to behavioral and cognitive deficits, the intermediary role of TAAR1 has yet to be characterized.
Nicholas B, Miner, Josh S, Elmore, Michael H, Baumann, Tamara J, Phillips, Aaron, Janowsky   +4 more
openaire   +2 more sources

Trace amine-associated receptor 1—Family archetype or iconoclast? [PDF]

Pharmacology & Therapeutics, 2007
Interest has recently been rekindled in receptors that are activated by low molecular weight, noncatecholic, biogenic amines that are typically found as trace constituents of various vertebrate and invertebrate tissues and fluids. The timing of this resurgent focus on receptors activated by the "trace amines" (TA) beta-phenylethylamine (PEA), tyramine (
openaire   +2 more sources

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.

PLoS ONE, 2016
Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and β-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1).
Xiao Shi, Nicole A R Walter, John H Harkness, Kim A Neve, Robert W Williams, Lu Lu, John K Belknap, Amy J Eshleman, Tamara J Phillips, Aaron Janowsky   +9 more
doaj   +1 more source

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs ...
Maria Qatato, Joanna Szumska, Vladislav Skripnik, Eddy Rijntjes, Josef Köhrle, Klaudia Brix   +5 more
doaj   +1 more source