Trace amine associated receptor 1 (TAAR1), a novel astrocyte receptor for METH-mediated neurotoxicity in HIV-1-associated neurocognitive disorders (HAND) [PDF]
, 2015 This dissertation explores the role of astrocyte trace amine associated receptor 1 (TAAR1), a novel G-protein coupled receptor (GPCR), in modulating the effects of methamphetamine (METH) on astrocyte-mediated excitotoxicity, thereby exacerbating HIV ...
Cisneros, Irma E.
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Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia [PDF]
Schizophrenia Research, 2017 Schizophrenia (SZ) is a chronic mental illness with behavioral abnormalities. Recent common variant based genome wide association studies and rare variant detection using next generation sequencing approaches have identified numerous variants that confer risk for SZ, but etiology remains unclear propelling continuing investigations.
Jibin John +6 more
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Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects. [PDF]
Neuropsychopharmacology, 2018 Nicotine addiction and abuse remains a global health issue. To date, the fundamental neurobiological mechanism of nicotine addiction remains incompletely understood. Trace amine-associated receptor 1 (TAAR1) is thought to directly modulate dopaminergic system and are thought to be a neural substrate underlying addictive-like behaviors.
Liu JF +10 more
europepmc +4 more sources
Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction [PDF]
European Journal of Pharmacology, 2015 Abuse of and addiction to psychostimulants remains a challenging clinical issue; yet no effective pharmacotherapy is available. Trace amine associated receptor 1 (TAAR 1) is increasingly recognized as a novel drug target that participates in the modulation of drug abuse.
Li, Jing, Jun-Xu, Li
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Trace amine-associated receptor 1 (TAAR1): a new drug target for psychiatry?
, 2021 Trace amine-associated receptor 1 (TAAR1): a new drug target for ...
Seetal Dodd (13093767) +6 more
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Frontiers in Pharmacology, 2018 Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines.
Julia Bräunig +10 more
doaj +1 more source
T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex
Neurobiology of Disease, 2021 Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer's disease (AD) and to be a risk factor for stroke.
Francesca Tozzi +5 more
doaj +1 more source
Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits [PDF]
Neuropsychopharmacology, 2015 Continued methamphetamine (MA) use is dependent on a positive MA experience and is likely attenuated by sensitivity to the aversive effects of MA. Bidirectional selective breeding of mice for high (MAHDR) or low (MALDR) voluntary consumption of MA demonstrates a genetic influence on MA intake.
John H Harkness +3 more
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Trace amine receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]
, 2019 Trace amine-associated receptors were discovered from a search for novel 5-HT receptors [9], where 15 mammalian orthologues were identified and divided into two families.
Maguire, Janet J. +4 more
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Evolutionary Conservation of 3-Iodothyronamine as an Agonist at the Trace Amine-Associated Receptor 1 [PDF]
European Thyroid Journal, 2015 Abstract Objectives: The trace amine-associated receptor 1 (Taar1) is a G<sub>s</sub> protein-coupled receptor activated by trace amines, such as β-phenylethylamine (β-PEA) and 3-iodothyronamine (T<sub>1</sub>AM).
Maxi, Cöster +3 more
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