Results 31 to 40 of about 1,835 (190)

Biological evaluation and in silico studies of novel compounds as potent TAAR1 agonists that could be used in schizophrenia treatment

Frontiers in Pharmacology, 2023
Introduction: Schizophrenia is a serious mental illness that requires effective treatment with minimal adverse effects. As preclinical and clinical research progresses, trace amine-associated receptor 1 (TAAR1) is becoming a potential new target for the ...
Yunjie Wang, Zhaofeng Liu, Jing Lu, Wenyan Wang, Lin Wang, Yifei Yang, Hongbo Wang, Liang Ye, Jianzhao Zhang, Jingwei Tian   +9 more
doaj   +1 more source

Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

eLife, 2019
We identified a locus on mouse chromosome 10 that accounts for 60% of the genetic variance in methamphetamine intake in mice selectively bred for high versus low methamphetamine consumption. We nominated the trace amine-associated receptor 1 gene, Taar1,
Alexandra M Stafford, Cheryl Reed, Harue Baba, Nicole AR Walter, John RK Mootz, Robert W Williams, Kim A Neve, Lev M Fedorov, Aaron J Janowsky, Tamara J Phillips   +9 more
doaj   +1 more source

Incretin-like effects of small molecule trace amine-associated receptor 1 agonists

Molecular Metabolism, 2016
Objective: Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies.
Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Basil Künnecke, Christoph Ullmer, Hugues Matile, Marc Bedoucha, Roger D. Norcross, Nickki Ottaway-Parker, Diego Perez-Tilve, Karin Conde Knape, Matthias H. Tschöp, Marius C. Hoener, Sabine Sewing   +15 more
doaj   +1 more source

Действие агониста TAAR1 RO 5263397 на дискинезию, вызываемую инъекцией α-NETA

Интегративная физиология, 2023
В настоящее время собрано достаточно данных о роли следовых аминов (СА) как нейромодуляторов в центральной нервной системе млекопитающих. СА имеют структурное сходство с классическими биогенными аминами, а изменения их концентрации связаны с различными ...
Надежда Владимировна Полякова, Антон Юрьевич Александров, Вероника Михайловна Князева, Екатерина Павловна Виноградова, Елена Сергеевна Дмитриева, Людмила Николаевна Станкевич, Александр Алексеевич Александров   +6 more
doaj   +1 more source

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs ...
Maria Qatato, Joanna Szumska, Vladislav Skripnik, Eddy Rijntjes, Josef Köhrle, Klaudia Brix   +5 more
doaj   +1 more source

Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine

Frontiers in Pharmacology, 2018
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity.
Michael D. Schwartz, Jeremiah B. Palmerston, Diana L. Lee, Marius C. Hoener, Thomas S. Kilduff   +4 more
doaj   +1 more source

Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets

Biomolecules, 2023
Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova, Taisiia S. Shemyakova, Karina V. Lenskaia, Roman N. Rodionov, Charlotte Steenblock, Raul R. Gainetdinov   +5 more
doaj   +1 more source

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

, 2011
The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and beta-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising
Gainetdinov, R. R., Pouzet, B., Wettstein, J. G., Zbinden, K. G., Trube, G., Norcross, R., Moreau, J. L., Mory, R., Metzler, V., Bruno Pouzet, Veit Metzler, Raul R. Gainetdinov, Jean-Luc Moreau, Hoener, M. C., Caron, M. G., Marc G. Caron, Joseph G. Wettstein, Katrin Groebke Zbinden, Roland Mory, Bradaia, A., Tatyana D. Sotnikova, Durkin, S., Florent G. Revel, Roger Norcross, Chaboz, S., Ozmen, L., Bernhard Bettler, Laurence Ozmen, Marius C. Hoener, Revel, F. G., Sean Durkin, Sylvie Chaboz, Gerhard Trube, Meyer, C. A., Bettler, B., Claas A. Meyer, Amyaouch Bradaia, Sotnikova, T. D.   +37 more
core   +1 more source

TAAR1 agonism blocks compulsive eating [PDF]

, 2016
Binge eating disorder (BED) is characterized by compulsive consumption of food within a short time period accompanied by loss of control over eating. Recent literature provides the basis for consideration of BED as an addiction-like disorder.
Howell, Adam
core   +1 more source

Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers

Frontiers in Pharmacology, 2018
Since its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell
Lisa M. Fleischer, Rachana D. Somaiya, Gregory M. Miller, Gregory M. Miller, Gregory M. Miller   +4 more
doaj   +1 more source