Results 51 to 60 of about 1,835 (190)

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.

PLoS ONE, 2019
BackgroundMethamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement ...
Jennifer M Loftis, Michael Lasarev, Xiao Shi, Jodi Lapidus, Aaron Janowsky, William F Hoffman, Marilyn Huckans   +6 more
doaj   +1 more source

Protein Metabolism Changes and Alterations in Behavior of Trace Amine-Associated Receptor 1 Knockout Mice Fed a High-Fructose Diet

Neurology International, 2023
Trace amines and their receptors are a family of G protein-coupled receptors widely distributed in the central nervous system and periphery. The trace amine-associated receptor 1 (TAAR1) plays a significant role as a therapeutic target for schizophrenia,
Sergey A. Apryatin, Ilya S. Zhukov, Ekaterina A. Zolotoverkhaya, Saveliy R. Kuvarzin, Temirkan A. Khunagov, Sanelya V. Ushmugina, Victor M. Klimenko   +6 more
doaj   +1 more source

A double‐blind study on ulotaront's impact on weight‐related parameters in schizophrenia patients with metabolic syndrome and prediabetes: Part II

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 94-102, January 2026.
Abstract Aims Antipsychotics increase metabolic syndrome (MetSyn) and diabetes risk. Preclinical and translational research data suggest that ulotaront, an investigational trace amine‐associated receptor 1 (TAAR1) agonist, may have beneficial metabolic effects.
Snezana Milanovic, Robert Lew, Kuangnan Xiong, Emily Casavant, Gerard Galluppi, Yu‐Luan Chen, Yongquan Lai, Manu Chakravarthy, Clay Dehn, Edward Jackson, Kenneth Koblan, Seth C. Hopkins   +11 more
wiley   +1 more source

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry and Clinical Implications

Frontiers in Neuroscience, 2016
Biogenic amines are a collection of endogenous molecules that play pivotal roles as neurotransmitters and hormones. In addition to the classical biogenic amines resulting from decarboxylation of aromatic acids, including dopamine (DA), norepinephrine ...
Yue ePei, Aman eAsif-Malik, Juan J Canales   +2 more
doaj   +1 more source

An open‐label study on ulotaront's effects on insulin‐glucose regulation in schizophrenia patients with metabolic syndrome and prediabetes: Part I

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 103-111, January 2026.
Abstract Aims Ulotaront is an investigational trace amine‐associated receptor 1 (TAAR1) agonist demonstrated to slow gastric emptying in schizophrenia patients with metabolic syndrome (MetSyn) and prediabetes type 2. Here we evaluate the effects of ulotaront on glucose‐insulin dynamics in schizophrenia patients with MetSyn and prediabetes.
Snezana Milanovic, Robert Lew, Kuangnan Xiong, Emily Casavant, Gerard Galluppi, Yu‐Luan Chen, Yongquan Lai, Manu Chakravarthy, Clay Dehn, Kenneth Koblan, Seth C. Hopkins   +10 more
wiley   +1 more source

Image_1_Behavioral Effects of a Potential Novel TAAR1 Antagonist.TIF

, 2018
The trace amine associated receptor 1 (TAAR1) is a G-protein coupled receptor expressed in the monoaminergic regions of the brain, and represents a potential novel therapeutic target for the treatment of neurological disorders.
Ali Salahpour (239589), Stefano Espinoza (239587), Wendy Horsfall (5712686), Corey Baimel (5712677), Pieter Beerepoot (5712680), Raul R. Gainetdinov (197947), Amy J. Ramsey (2002120), Stephanie L. Borgland (694529), Ilya Sukhanov (5712683), Vincent M. Lam (5712674), Catharine A. Mielnik (3193638)   +10 more
core   +1 more source

Data_Sheet_1_Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors.pdf

, 2021
Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention.
Tamara J. Phillips (11333976), John R. K. Mootz (11333988), Jason Erk (392532), Cheryl Reed (11333991), Sara J. Aldrich (11333982), Elissa J. Chesler (9103778), Tyler Roy (11333979), Harue Baba (11333985)   +7 more
core   +1 more source

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine

Frontiers in Pharmacology, 2018
The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized.
Xiaoqun Zhang, Ioannis Mantas, Alexandra Alvarsson, Takashi Yoshitake, Mohammadreza Shariatgorji, Marcela Pereira, Anna Nilsson, Jan Kehr, Per E. Andrén, Mark J. Millan, Karima Chergui, Per Svenningsson   +11 more
doaj   +1 more source

Discovery of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 2-(5-(4′-Chloro-[1,1′-biphenyl]-4-yl)-4H-1,2,4-triazol-3-yl)ethan-1-amine (LK00764) for the Treatment of Psychotic Disorders

Biomolecules, 2022
A focused in-house library of about 1000 compounds comprising various heterocyclic motifs in combination with structural fragments similar to β-phenylethylamine or tyramine was screened for the agonistic activity towards trace amine-associated receptor 1
Mikhail Krasavin, Alexey Lukin, Ilya Sukhanov, Andrey S. Gerasimov, Savelii Kuvarzin, Evgeniya V. Efimova, Mariia Dorofeikova, Anna Nichugovskaya, Andrey Matveev, Kirill Onokhin, Konstantin Zakharov, Maxim Gureev, Raul R. Gainetdinov   +12 more
doaj   +1 more source