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Comparative Analysis of Antidepressant Mechanisms and Side Effects: Network Pharmacology and Molecular Docking Study of Amitriptyline, Mirtazapine, and Escitalopram for Treating Major Depressive Disorder

Depression and Anxiety, Volume 2026, Issue 1, 2026.
Background Amitriptyline, mirtazapine, and escitalopram are effective antidepressants for treating major depressive disorder (MDD). Our study aimed to use computational biology to understand the mechanisms for the similarities and differences in efficacies and side effects of these drugs.
Chuanjun Zhuo +11 more
wiley +1 more source

TAAR1 induces a disturbed GSK3 β phosphorylation in recurrent miscarriages through the ODC [PDF]

, 2018
Objectives: Thyroid hormones play an important role in the maintenance of pregnancy. Their derivates, endogenous amines, act via binding to the trace amine-associated receptor (TAAR1).
Simone Hofmann +27 more
core +1 more source

Opportunities and challenges in the design of selective TAAR1 agonists: an editorial [PDF]

Expert Opinion on Therapeutic Patents, 2018
Nowadays, compounds targeting G-protein-coupled receptors (GPCRs) represent a large amount of clinically relevant drugs, depicting a leading role in the drug discovery panorama.Trace amine-associat...
openaire +3 more sources

The Relationship Between Olfactory Dysfunction and Cognitive Decline: Impacts, Mechanisms, and Potential Interventions

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Olfactory dysfunction (OD) has been identified as a potential indicator closely related to cognitive decline (CD). This review explores the complex connection between olfactory and cognitive function, with a focus on the nose–brain axis. We summarize recent evidence linking OD of various etiologies to CD and discuss how this relationship depends on the
Chenyang Lei +6 more
wiley +1 more source

Image_2_Behavioral Effects of a Potential Novel TAAR1 Antagonist.TIF

, 2018
The trace amine associated receptor 1 (TAAR1) is a G-protein coupled receptor expressed in the monoaminergic regions of the brain, and represents a potential novel therapeutic target for the treatment of neurological disorders.
Ali Salahpour (239589) +10 more
core +1 more source

TAAR1-dependent astrocyte dysregulation during HAND and METH exposure [PDF]

, 2018
Excitatory amino-acid transporter (EAAT)-2 is predominantly expressed in astrocytes and clears glutamate from tripartite synapses preventing excitotoxicity.
Mythen, Shannon
core +2 more sources

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

Frontiers in Pharmacology, 2018
Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines.
Julia Bräunig +10 more
doaj +1 more source

Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis

Arthritis Care &Research, Volume 77, Issue 12, Page 1409-1417, December 2025.
Objective Several single‐nucleotide polymorphisms (SNPs) have been associated with chronic pain syndromes. Our objective was to determine whether genetic variants are associated with pain and disease activity in rheumatoid arthritis (RA). Methods Participants were included from two independent RA cohorts: FORWARD (National Databank for Rheumatic ...
Katie J. McMenamin +15 more
wiley +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

, 2015
Trace amine-associated receptor 1 (TAAR1) activation by selective endogenous agonists modulates dopaminergic neurotransmission. This results in antipsychotic-like behavior in vivo which might be initiated by an interaction of TAAR1 and dopamine D2L ...
Chaboz, S. +11 more
core +1 more source

trace amine-associated receptor 1
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trace amines

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trace amine-associated receptor 1 taar1