Results 81 to 90 of about 1,835 (190)

Trace Amine-Associated Receptor 1 Agonist Modulates Mismatch Negativity-Like Responses in Mice

Frontiers in Pharmacology, 2019
The trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor widely expressed in the mammalian brain, particularly in limbic system and monoaminergic areas.
Aleksander A. Aleksandrov, Veronika M. Knyazeva, Anna B. Volnova, Elena S. Dmitrieva, Nadezhda V. Polyakova, Raul R. Gainetdinov   +5 more
doaj   +1 more source

Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data [version 1; peer review: 2 approved]

Wellcome Open Research
Background Trace amine-associated receptor 1 (TAAR1) agonism shows promise for treating psychosis, prompting us to synthesise data from human and non-human studies.
Fiona J. Ramage, Spyridon Siafis, Edoardo G. Ostinelli, Virginia Chiocchia, Claire Stansfield, Simonne Wright, Ioannis Mantas, Damian Omari Juma, Grazia Rutigliano, Oliver D. Howes, Francesca Tinsdeall, Lea Milligan, Claire Friedrich, Julian H. Elliott, Carmen Moreno, Ava Homiar, James Thomas, Emily S. Sena, Malcolm R. Macleod, Charlotte Austin, Nobuyuki Nomura, Jaycee Kennett, Soraya Seedat, Luke J. Vano, Andrea Cipriani, Olena Maksym, Jennifer Potts, David Gilbert, Thomy Tonia, Robert A. McCutcheon, Matthias Egger, Stefan Leucht, Toshi A. Furukawa, Hossein Dehdarirad, Janna Hastings, Susan Michie, Georgia Salanti, Olufisayo Elugbadebo, Ouma Simple   +38 more
doaj   +1 more source

Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor, which signals through elevating intracellular cAMP levels, and expressed in most vertebrates, including rodents and humans.
Stefano Espinoza, Damiana Leo, Damiana Leo, Tatyana D. Sotnikova, Mohammed Shahid, Tiina M. Kääriäinen, Raul R. Gainetdinov, Raul R. Gainetdinov   +7 more
doaj   +1 more source

Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations

Human Genomics
Trace Amine Associated Receptor 1 (TAAR1) is a novel pharmaceutical target under investigation for the treatment of several neuropsychiatric conditions.
Britto Shajan, Shashikanth Marri, Tarun Bastiampillai, Karen J. Gregory, Shane D. Hellyer, Pramod C. Nair   +5 more
doaj   +1 more source

Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

PLoS ONE, 2011
Trace amine-associated receptors (TAAR) are rhodopsin-like G-protein-coupled receptors (GPCR). TAAR are involved in modulation of neuronal, cardiac and vascular functions and they are potentially linked with neurological disorders like schizophrenia and ...
Gunnar Kleinau, Juliane Pratzka, Daniela Nürnberg, Annette Grüters, Dagmar Führer-Sakel, Heiko Krude, Josef Köhrle, Torsten Schöneberg, Heike Biebermann   +8 more
doaj   +1 more source

Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs

BMC Evolutionary Biology, 2010
Background The trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor that acts as a modulator in brain ...
Westmoreland Susan V, Xie Zhihua, Vallender Eric J, Miller Gregory M   +3 more
doaj   +1 more source

The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules

Cell Reports
Summary: Increasing global concerns about psychoactive substance addiction and psychotic disorders highlight the need for comprehensive research into the structure-function relationship governing ligand recognition between these substances and their ...
Kexin Jiang, You Zheng, Liting Zeng, Ling Wang, Fei Li, Jun Pu, Yingli Lu, Suwen Zhao, Fei Xu   +8 more
doaj   +1 more source

TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding

Molecular Metabolism
Objective: Metabolic Syndrome, which can be induced or exacerbated by current antipsychotic drugs (APDs), is highly prevalent in schizophrenia patients.
Nina Dedic, Lien Wang, Eva Hajos-Korcsok, Jacob Hecksher-Sørensen, Urmas Roostalu, Steven P. Vickers, Serena Wu, Christoph Anacker, Colleen Synan, Philip G. Jones, Snezana Milanovic, Seth C. Hopkins, Linda J. Bristow, Kenneth S. Koblan   +13 more
doaj   +1 more source

Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol

Substance Abuse: Research and Treatment, 2013
Background Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and ...
Laurie J. Lynch, Katherine A. Sullivan, Eric J. Vallender, James K. Rowlett, Donna M. Platt, Gregory M. Miller   +5 more
doaj   +1 more source

A Pilot Study on a Possible Mechanism behind Olfactory Dysfunction in Parkinson’s Disease: The Association of TAAR1 Downregulation with Neuronal Loss and Inflammation along Olfactory Pathway

Brain Sciences
Parkinson’s disease (PD) is characterized not only by motor symptoms but also by non-motor dysfunctions, such as olfactory impairment; the cause is not fully understood.
Mei-Xuan Zhang, Hui Hong, Yun Shi, Wen-Yan Huang, Yi-Meng Xia, Lu-Lu Tan, Wei-Jiang Zhao, Chen-Meng Qiao, Jian Wu, Li-Ping Zhao, Shu-Bing Huang, Xue-Bing Jia, Yan-Qin Shen, Chun Cui   +13 more
doaj   +1 more source