Results 91 to 100 of about 1,835 (190)

Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep

Frontiers in Psychiatry
IntroductionThis study aimed to investigate the role of TAAR2-9 in sleep/wake regulation, given TAAR1's known involvement in modulating neurotransmitter release and sleep patterns.MethodsMale TAAR2-9 knockout (KO) and wild-type (WT) mice were compared ...
Sunmee Park, Jasmine Heu, Gavin Scheldrup, Ryan K. Tisdale, Yu Sun, Meghan Haire, Shun-Chieh Ma, Marius C. Hoener, Thomas S. Kilduff   +8 more
doaj   +1 more source

New Modulators of TAAR1: Meta Linked Ureas

, 2013
A naturally occurring thyroid hormone (TH) metabolite, 3-Iodothyronamine (T1AM), is a fast acting derivative which activates the Trace Amine Associated Receptor (TAAR1). In mice, T1AM exhibits effects opposite of those induced by TH.
Williams, Jacqueline
core  

Molecular Mechanisms of Methamphetamine-Induced Addiction via TAAR1 Activation

Journal of Medicinal Chemistry
Trace amine-associated receptor 1 (TAAR1), a member of the trace amine receptor family, recognizes various trace amines in the brain, including endogenous β-phenylethylamine (PEA) and methamphetamine (METH). TAAR1 is a novel target for several neurological disorders, including schizophrenia, depression, and substance abuse.
Yun Lin, Jiening Wang, Fan Shi, Linlin Yang, Shan Wu, Anna Qiao, Sheng Ye   +6 more
openaire   +2 more sources

Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [F]DOPA PET in Naïve and Cocaine-Treated Mice

Molecular Imaging
Purpose Elevated dopamine synthesis capacity is part of the pathophysiology of schizophrenia thought to underlie psychosis. Drugs that reduce this phenomenon could thus be potential treatments for these disorders.
David R. Bonsall PhD, Michelle Kokkinou PhD, Els F. Halff PhD, Grazia Rutigliano PhD, Sac-Pham Tang MSc, Mattia Veronese PhD, Elaine E. Irvine PhD, Dominic J. Withers FRCP, PhD, Lisa A. Wells PhD, Sridhar Natesan PhD, Irene Gerlach PhD, Štefan Holiga PhD, Marius C. Hoener PhD, Oliver D. Howes MRCpsych, PhD   +13 more
doaj   +1 more source

Correction To: TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT1A receptor agonist SEP- 363856

Neuropsychopharmacology, 2022
Saarinen, Marcus, Mantas, Ioannis, Flais, Ivana, Ågren, Richard, Sahlholm, Kristoffer, Millan, Mark J., Svenningsson, Per   +6 more
openaire   +1 more source

Wakefulness Induced by TAAR1 Partial Agonism in Mice Is Mediated Through Dopaminergic Neurotransmission

Trace amine-associated receptor 1 (TAAR1) is a negative regulator of dopamine (DA) release. The partial TAAR1 agonist RO5263397 promotes wakefulness and suppresses NREM and REM sleep in rodents and non-human primates.
Park, Sunmee, Marius C. Hoener, Heu, Jasmine, Jasmine Heu, Kilduff, Thomas S., Thomas S. Kilduff, Hoener, Marius C., Sunmee Park   +7 more
core   +1 more source

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system

, 2009
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids. TAAR1 is considered a promising drug target for the treatment of psychiatric and neurodegenerative
Ozmen, Laurence, Wettstein, Joseph G., Stalder, Henri, Trube, Gerhard, Norcross, Roger D., Bettler, Bernhard, Hoener, Marius C., Buchy, Danièle, Gassmann, Martin, Bradaia, Amyaouch, Pinard, Audrée   +10 more
core  

Elucidating molecular mechanisms of TAAR1-dependent astrocyte regulation during HIV-associated neurocognitive disorders and methamphetamine exposure

, 2018
Elucidating molecular mechanisms of TAAR1-dependent astrocyte regulation during HIV-associated neurocognitive disorders and methamphetamine exposure Shannon Mythen and Anuja Ghorpade Department of Microbiology, Immunology and Genetics, UNT Health ...
Mythen, Shannon, Ghorpade, Anuja
core  

Structure based discovery of antipsychotic-like TAAR1 agonists. [PDF]

Nat Commun
Huang S, Liu H, Wu Y, Braz JM, Kranthi D, Hall BW, Zhang X, Radchenko DS, Moroz YS, Irwin JJ, Basbaum AI, Xu HE, Wetsel WC, Shoichet BK.   +13 more
europepmc   +1 more source

Влияние нокаута гена TAAR1 на характеристики поведения мышей в тесте Порсолта и в приподнятом крестообразном лабиринте

Целью данного исследования явилось изучение функциональной роли рецептора TAAR1, одного из представителей рецепторов следовых аминов (trace amine–associated receptors, TAARs).
Симон, Юлия Александровна, Маркина, Алиса Александровна, Александров, Александр Алексеевич, Виноградова, Екатерина Павловна, Иоффе, Вероника Станиславовна, Козырева, Анна Владимировна, Александров, Антон Юрьевич, Князева, Вероника Михайловна, Станкевич, Людмила Николаевна   +8 more
core   +1 more source