Results 71 to 80 of about 1,835 (190)
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.Structure of lisdexamfetamine dimesylate, its active metabolite d‐amphetamine and the essential amino acid l‐lysine, along with the mechanism of action and primary pharmacological and adverse effects associated with lisdexamfetamine dimesylate. TAAR1, trace amine‐associated receptor; VMAT, vesicular monoamine transporter; DAT, dopamine transporter; NAT,
Mariana Silva‐Carvalho +3 more
wiley +1 more source
Table_1_Behavioral Effects of a Potential Novel TAAR1 Antagonist.docx
, 2018 The trace amine associated receptor 1 (TAAR1) is a G-protein coupled receptor expressed in the monoaminergic regions of the brain, and represents a potential novel therapeutic target for the treatment of neurological disorders.
Ali Salahpour (239589) +10 more
core +1 more source
Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products
European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez +1 more
wiley +1 more source
, 2023 (A) Proposed mechanism of the pathologic effects of Meth on cardiomyocytes, including the upregulation of cardiac fibrosis via lysyl oxidase and the increased frequency of arrhythmia via the calmodulin CaMKII. cAMP, the upstream factor for both processes,
Xing Xia (2274457) +7 more
core +1 more source
The existing available antipsychotics have failed to manage the cognitive impairment of schizophrenia and induced a number of seriously undesirable effects.
Weifeng Zhang (134361) +10 more
core +4 more sources
Ligand Recognition and Function of TAARs
Sensory Neuroscience, Volume 1, Issue 2, September 2025.The trace amine‐associated receptor (TAAR) family represents a highly conserved group of G protein‐coupled receptors (GPCRs) in vertebrates. TAARs specifically bind to different amine ligands and mediate a variety of physiological and behavioral processes.
Kang‐Ying Qian +3 more
wiley +1 more source
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.A trace amine beta‐phenylethylamine is anxiolytic and reduces brain acetylcholine at 12 μg/L, but elevates anxiety and cortisol levels at 1000 μg/L. Acute tryptamine at 7 mg/L is anxiogenic, reduces shoaling and social interaction, but elevates brain acetylcholine and cortisol levels. Acute tyramine at 15 μg/L, and octopamine at 125, 500, and 1500 μg/L,
Thalia M. Quintanilha +10 more
wiley +1 more source
Advanced Science, Volume 12, Issue 17, May 8, 2025.This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li +3 more
wiley +1 more source
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
MedComm, Volume 6, Issue 5, May 2025.ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen +5 more
wiley +1 more source
Frontiers in PsychiatryFor over seven decades, dopamine receptor 2 (D2 receptor) antagonists remained the mainstay treatment for neuropsychiatric disorders. Although it is effective for treating hyperdopaminergic symptoms, it is often ineffective for treating negative and ...
Britto Shajan +7 more
doaj +1 more source