Results 11 to 20 of about 1,835 (190)

TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg [PDF]

Frontiers in Pharmacology, 2018
Trace-amine associated receptor 1 (TAAR1) is the best-characterized member of the family of TAARs. TAAR1 is broadly expressed in the brain, especially within the monoaminergic systems.
Jian-Feng Liu, Jian-Feng Liu, Jun-Xu Li
doaj   +4 more sources

Behavioral Effects of a Potential Novel TAAR1 Antagonist [PDF]

Frontiers in Pharmacology, 2018
The trace amine associated receptor 1 (TAAR1) is a G-protein coupled receptor expressed in the monoaminergic regions of the brain, and represents a potential novel therapeutic target for the treatment of neurological disorders.
Vincent M. Lam, Catharine A. Mielnik, Corey Baimel, Pieter Beerepoot, Pieter Beerepoot, Stefano Espinoza, Ilya Sukhanov, Ilya Sukhanov, Wendy Horsfall, Raul R. Gainetdinov, Stephanie L. Borgland, Amy J. Ramsey, Ali Salahpour   +12 more
doaj   +8 more sources

The Case for TAAR1 as a Modulator of Central Nervous System Function [PDF]

Frontiers in Pharmacology, 2018
TAAR1 is widely expressed across the mammalian brain, particularly in limbic and monoaminergic areas, allegedly involved in mood, attention, memory, fear, and addiction.
Grazia Rutigliano, Grazia Rutigliano, Alice Accorroni, Alice Accorroni, Riccardo Zucchi   +4 more
doaj   +4 more sources

Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia [PDF]

ACS Medicinal Chemistry Letters, 2021
Ulotaront (SEP-363856) is a trace-amine associated receptor 1 (TAAR1) agonist with 5-HT1A receptor agonist activity in Phase 3 clinical development, with FDA Breakthrough Therapy Designation, for the treatment of schizophrenia.
Kenneth S. Koblan, Philip G. Jones (9901203), Seth C. Hopkins (1960489), Michael C. Hewitt, Seth C. Hopkins, Lee W. Herman (11799289), Linghong Xie, Liming Shao, Michele L. R. Heffernan (11799286), Linghong Xie (3037746), Scott Brown, Nina Dedic, Nina Dedic (658034), Scott Brown (1922701), John E. Campbell, Michele L. R. Heffernan, Philip G. Jones, Liming Shao (541157), Kenneth S. Koblan (265093), Michael C. Hewitt (1912948), John E. Campbell (1370379), Lee W. Herman   +21 more
core   +3 more sources

TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT1A receptor agonist SEP-383856 [PDF]

Neuropsychopharmacology, 2022
SEP-383856 (SEP-856) is a novel antipsychotic under clinical development. It displays a unique pattern of receptor interaction, with only weak (partial agonist) activity at dopamine D2 receptors, yet more potent agonist activity at the trace amine ...
Flais, Ivana, Ågren, Richard, Sahlholm, Kristoffer, Millan, Mark J., Saarinen, Marcus,, Mantas, Ioannis, Millan, Mark J.,, Ågren, Richard,, Flais, Ivana,, Sahlholm, Kristoffer,, Saarinen, Marcus, Svenningsson, Per, Svenningsson, Per,, Mantas, Ioannis,   +13 more
core   +5 more sources

TAAR1 Modulates Cortical Glutamate NMDA Receptor Function [PDF]

Neuropsychopharmacology, 2015
Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor expressed in the mammalian brain and known to influence subcortical monoaminergic transmission.
L. Medrihan, Ronzitti, Giuseppe, A. Harmeier, Giuseppe Ronzitti, Sotnikova, Tatyana D, Leo, Damiana, Gainetdinov, Raul R., R. R. Gainetdinov, Valter Tucci, G. Lignani, Hoener, Marius C, Maggi, Silvia, Espinoza, Stefano, T. D. Sotnikova, Sukhanov, Ilya, Marius C Hoener, Fabio Benfenati, Gabriele Lignani, Emanuele, Marco, L. Mus, Fumagalli, Fabio, Benfenati, Fabio, S. Espinoza, Ilya Sukhanov, F. Fumagalli, Tatyana D Sotnikova, M. Emanuele, Sotnikova, Tatyana D., Fabio Fumagalli, V. Tucci, Gainetdinov, Raul R, Anja Harmeier, Medrihan, Lucian, Harmeier, Anja, G. Ronzitti, E. Chieregatti, Chieregatti, Evelina, I. Sukhanov, Lignani, Gabriele, Caffino, Lucia, Silvia Maggi, F. Benfenati, Lucian Medrihan, Evelina Chieregatti, Stefano Espinoza, S. Maggi, M. C. Hoener, Hoener, Marius C., Raul R Gainetdinov, Liudmila Mus, D. Leo, Tucci, Valter, Marco Emanuele, Lucia Caffino, L. Caffino, Mus, Liudmila, Damiana Leo   +56 more
core   +6 more sources

Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward

Frontiers in Pharmacology, 2018
Eating disorders and some forms of obesity are characterized by addictive-like, compulsive eating behavior which contains numerous similarities with compulsive drug use.
Catherine F. Moore, Catherine F. Moore, Valentina Sabino, Pietro Cottone   +3 more
doaj   +2 more sources

Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration

Breast Cancer: Targets and Therapy, 2019
Eileen Tremmel,1 Simone Hofmann,1 Christina Kuhn,1 Helene Heidegger,1 Sabine Heublein,2 Kerstin Hermelink,1 Rachel Wuerstlein,1 Nadia Harbeck,1 Doris Mayr,3 Sven Mahner,1 Nina Ditsch,1 Udo Jeschke,1 Aurelia Vattai1 1Breast Center, Department of ...
Tremmel E, Hofmann S, Kuhn C, Heidegger H, Heublein S, Hermelink K, Wuerstlein R, Harbeck N, Mayr D, Mahner S, Ditsch N, Jeschke U, Vattai A   +12 more
doaj   +1 more source

Dopamine Receptors and TAAR1 Functional Interaction Patterns in the Duodenum Are Impaired in Gastrointestinal Disorders

Biomedicines
Currently, there is a growing amount of evidence for the involvement of dopamine receptors and the functionally related trace amine-associated receptor, TAAR1, in upper intestinal function.
Anastasia N. Vaganova, Alisa A. Markina, Aleksandr M. Belousov, Karina V. Lenskaia, Raul R. Gainetdinov   +4 more
doaj   +2 more sources

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1 [PDF]

Frontiers in Pharmacology, 2017
Activation of trace amine-associated receptor 1 (TAAR1) in endocrine pancreas is involved in weight regulation and glucose homeostasis. The purpose of this study was the identification and characterization of potential TAAR1 variants in patients with ...
Jessica Mühlhaus, Juliane Dinter, Sabine Jyrch, Alexander Teumer, Simon F. Jacobi, Georg Homuth, Peter Kühnen, Susanna Wiegand, Annette Grüters, Henry Völzke, Henry Völzke, Klemens Raile, Klemens Raile, Gunnar Kleinau, Gunnar Kleinau, Heiko Krude, Heike Biebermann   +16 more
doaj   +4 more sources