Results 91 to 100 of about 4,682,301 (303)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

The Relationship Between Pedestrian’s Assessment of Street Environments and Physical Conditions [PDF]

open access: yes, 1987
1.1.1 Any new road, road improvement or traffic management scheme could affect pedestrian journeys in its locality or elsewhere. Some journeys may be affected directly, with severance caused where the new road or road improvement cuts across a ...
Hopkinson, P.G., May, A.D., Turvey, I.G.
core  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

Evaluation of the Effect of Project Management Techniques on Road Construction Projects in Nigeria [PDF]

open access: yesEuropean Project Management Journal, 2017
Project management is an innovative management practice that tends to achieve stated or specified objectives within specific time and budget limits through optimum use of resources. The aim of the study was to investigate the effect of project management
Onifade Morakinyo Kehinde   +2 more
doaj  

The Challenges and Obstacles of Post-Disaster Road Infrastructure Reconstruction in the Pre-Construction Phase [PDF]

open access: yes, 2015
Purpose The reconstruction of road infrastructure in the post-disaster context require different approach when compared with road projects in the normal development context.
Amaratunga, Dilanthi   +2 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Evaluating Differences in Household Subsistence Harvest Patterns between the Ambler Project and Non-Project Zones [PDF]

open access: yes, 2016
Western Alaska is one of largest inhabited, roadless areas in North America and, indeed, the world. Access, via a new road that would transverse Gates of the Arctic National Park and Preserve (GAAR), to a mining district in a vast roadless section of ...
Greenberg, Joshua   +3 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

KAJIAN PENERAPAN ZoSS (ZONA SELAMAT SEKOLAH) DI KOTA BOGOR [PDF]

open access: yes, 2009
Placing of (location) school facility (elementary school) as basic equipment facilitation of environment is sometimes accessible to road gives feeling of insecure/unsafe, cause of its impact on interaction conflict within its user (especially toward ...
SUPRAPTO, AGUS
core  

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

open access: yesAging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

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