Results 71 to 80 of about 4,682,301 (303)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A functional road classification with data mining techniques
Transport, 2014 The current international road standards, in order to give organization and safety, promote the classification of roads according to their technical and functional characteristics beyond their administrative membership, but the procedures are yet ...
Antonino D’Andrea +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Economically Optimal Road Subnetwork
Communications, 2014 The paper deals with the following situation: An area is served by a transportation network, usually the road one. The current quality of the network is not satisfactory for the owner (e.g.
Anna Cerna, Jan Cerny, Vladimir Pribyl
doaj +1 more source
Review of current practices in recording road traffic incident data: with specific reference to spatial analysis and road policing policy [PDF]
, 2003 Road safety involves three major components: the road system, the human factor and the vehicle element. These three elements are inter-linked through geo-referenced traffic events and provide the basis for road safety analyses and attempts to reduce ...
Anderson, Tessa
core +1 more source
New Applications of Radio Frequency Identification Stations for Monitoring Fish Passage through Headwater Road Crossings and Natural Reaches [PDF]
, 2018 Within the Ouachita National Forest, roads and streams intersect each other thousands of times. Many of these road crossings alter stream hydrology and potentially limit longitudinal fish movement.
Gagen, Charles J, MacLeod, Ian R
core +4 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Development of Intelligent Transport Systems in Russia: problems and solutions. New stage
Интеллект. Инновации. Инвестиции, 2020 The situation with the development of intelligent transport systems (ITS) in Russia is characterized. The main problems of the development of ITS in our country are considered.
A. I. Solodkiy
doaj +1 more source
Road: artists and the stop the M11 link road campaign 1984 - 1994 [PDF]
, 2012 The project 'Road' is an archive of text, images and oral recordings that document the living history of the 'No M11 Link Road' campaign in East London (Leyton, Leytonstone and Wanstead) from 1984 to 1995, and the people that lived in and visited the ...
Liley, Hannah +2 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source