Results 31 to 40 of about 1,197,719 (300)

Does the threat of disqualification deter drivers from speeding? [PDF]

open access: yes, 2008
Road Safety Research Report, number 96, is available from the National Archives: Department for Transport, and can be accessed from the link below.It has long been recognised that driving speeds that are excessive and inappropriate to the conditions are
Corbett, C   +3 more
core   +1 more source

On-stack replacement, distilled [PDF]

open access: yes, 2018
On-stack replacement (OSR) is essential technology for adaptive optimization, allowing changes to code actively executing in a managed runtime. The engineering aspects of OSR are well-known among VM architects, with several implementations available to ...
Bhandari Abhilash   +14 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Geotechnical Problems Of The Foundation Of Road Embankments By The Bridge Structures

open access: yesStudia Geotechnica et Mechanica, 2019
This work presents the geotechnical problems occurring in the interaction area between road embankments and the bridge structures in case a subsoil characterised by complex and complicated geological and engineering conditions. These significant problems
Batog Andrzej, Stilger-Szydło Elżbieta
doaj   +1 more source

Review of current practices in recording road traffic incident data: with specific reference to spatial analysis and road policing policy [PDF]

open access: yes, 2003
Road safety involves three major components: the road system, the human factor and the vehicle element. These three elements are inter-linked through geo-referenced traffic events and provide the basis for road safety analyses and attempts to reduce ...
Anderson, Tessa
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Road landscape and engineering system Kyiv-Odesa: functioning, current geochemical state, problems of rational use

open access: yesВісник Харківського національного університету імені В.Н. Каразіна. Серія Геологія. Географія. Екологія
Formulation of the problem. The Kyiv-Odesa road landscape engineering system, one of the most powerful within Ukraine, is an optimal model for detailed studies of such status.
Hrigoriy Denysyk   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

UTILIZATION OF ROCKS IN ROAD ENGINEERING [PDF]

open access: yesActa Montanistica Slovaca, 1997
Mineral properties influence their usage in the road pavement construction decisincly. Demands for minerals are very different depending on the strain type in the pavement.
Romancová Iveta, Grünner Karol
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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