Results 41 to 50 of about 191,183 (260)

Application of Phosphogypsum-Based Modified Materials in Road Engineering of China

Advances in Civil Engineering
To determine the research status of phosphogypsum-based materials in Chinese road engineering, this article introduces the physicochemical properties of phosphogypsum materials, analyzes its strength formation mechanism, and evaluates its road ...
Zhenyu Du, Wanqing Huang, Mingming Cao
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Performance analysis and prediction of asphalt pavement containing municipal solid waste incineration bottom ash aggregate based on MEPDG

Scientific Reports
Municipal solid waste incinerator (MSWI) bottom ash (BA) is the main product of municipal solid waste after being burned. MSWI bottom ash aggregate (BAA) which is made from processed BA can be used in road engineering due to its strength and gradation ...
Yu Sun, Luo Ji, Jian Liao, Fulong Zhang, Yan Gao, Chongwei Huang   +5 more
doaj   +1 more source

Road MAPs to engineer host microbiomes

Current Opinion in Microbiology, 2018
Microbiomes contribute directly or indirectly to host health and fitness. Thus far, investigations into these emergent traits, referred to here as microbiome-associated phenotypes (MAPs), have been primarily qualitative and taxonomy-driven rather than quantitative and trait-based.
Oyserman, Ben O., Medema, Marnix H., Raaijmakers, Jos M.   +2 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Automatic Estimation of Excavation Volume from Laser Mobile Mapping Data for Mountain Road Widening

Remote Sensing, 2013
Roads play an indispensable role as part of the infrastructure of society. In recent years, society has witnessed the rapid development of laser mobile mapping systems (LMMS) which, at high measurement rates, acquire dense and accurate point cloud data ...
Massimo Menenti, Pedro Arias-Sánchez, Higinio González-Jorge, Roderik Lindenbergh, Jinhu Wang   +4 more
doaj   +1 more source

Research on prediction of WMA mixing temperature or additive dosage using digital image recognition of coating rate

Materials Research Express, 2022
It is difficult to determine a reasonable mixing temperature for WMA based solely on the viscosity-temperature relationship of the binder, as is the case for HMA, and it is a more reasonable solution to determine the mixing temperature of WMA by the ...
Liming Wang, Jinling Kang, Yibing Fan, Kun Ma, Chun Gong   +4 more
doaj   +1 more source