Results 51 to 60 of about 1,196,320 (300)

Exploring Knowledge Engineering Strategies in Designing and Modelling a Road Traffic Accident Management Domain [PDF]

, 2013
Formulating knowledge for use in AI Planning engines is currently something of an ad-hoc process, where the skills of knowledge engineers and the tools they use may significantly influence the quality of the resulting planning application.
Chrpa, Lukáš, Kitchin, Diane E., McCluskey, T.L., Shah, Mohammad Munshi Shahin, Vallati, Mauro   +4 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Pavement Engineering for Forest Roads [PDF]

Croatian journal of forest engineering, 2020
Pavement is an essential component of roads as it carries the traffic and provides the required riding comfort. Considering that numerous forest roads are approaching their end of life, the critical issue is identifying the best rational pavement design methods to reengineer existing and build new pavement structures.
openaire   +4 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

PROFESSOR AHMAD FARHAN BESTOWED ROAD SAFETY ICON AWARD [PDF]

, 2015
PENANG, 1 April 2015 The Dean of the School of Civil Engineering, Universiti Sains Malaysia (USM), Professor Dr. Ahmad Farhan Mohd Sadullah has been chosen by the Malaysian Road Transport Department (JPJ) as the Road Safety Icon for his contributions ...
MPRC, Pusat Media & Perhubungan Awam
core  

Non-invasive characterisation of road subgrade with towed-array capacitive resistivity imaging [PDF]

, 2004
A towed-array Capacitive Resistivity Imaging (CRI) system has been used in a controlled experiment to acquire multi-channel high-resolution ERT data on an asphalt road. Results from a CRI survey on a purpose-built trial road are discussed and compared to
Beamish, D., Kuras, O., Meldrum, P.I., Ogilvy, R.D.   +3 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Road MAPs to engineer host microbiomes

Current Opinion in Microbiology, 2018
Microbiomes contribute directly or indirectly to host health and fitness. Thus far, investigations into these emergent traits, referred to here as microbiome-associated phenotypes (MAPs), have been primarily qualitative and taxonomy-driven rather than quantitative and trait-based.
Oyserman, Ben O., Medema, Marnix H., Raaijmakers, Jos M.   +2 more
openaire   +2 more sources