Results 71 to 80 of about 4,462,462 (332)

Testing and Debugging Quantum Programs: The Road to 2030 [PDF]

ACM Transactions on Software Engineering and Methodology
Quantum computing has existed in the theoretical realm for several decades. Recently, quantum computing has re-emerged as a promising technology to solve problems that a classical computer could take hundreds of years to solve.
Neilson Carlos Leite Ramalho, Higor Amario de Souza, Marcos Lordello Chaim   +2 more
semanticscholar   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Non-invasive characterisation of road subgrade with towed-array capacitive resistivity imaging [PDF]

, 2004
A towed-array Capacitive Resistivity Imaging (CRI) system has been used in a controlled experiment to acquire multi-channel high-resolution ERT data on an asphalt road. Results from a CRI survey on a purpose-built trial road are discussed and compared to
Beamish, D., Kuras, O., Meldrum, P.I., Ogilvy, R.D.   +3 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Road MAPs to engineer host microbiomes

Current Opinion in Microbiology, 2018
Microbiomes contribute directly or indirectly to host health and fitness. Thus far, investigations into these emergent traits, referred to here as microbiome-associated phenotypes (MAPs), have been primarily qualitative and taxonomy-driven rather than quantitative and trait-based.
Oyserman, Ben O., Medema, Marnix H., Raaijmakers, Jos M.   +2 more
openaire   +2 more sources

PROFESSOR AHMAD FARHAN BESTOWED ROAD SAFETY ICON AWARD [PDF]

, 2015
PENANG, 1 April 2015 The Dean of the School of Civil Engineering, Universiti Sains Malaysia (USM), Professor Dr. Ahmad Farhan Mohd Sadullah has been chosen by the Malaysian Road Transport Department (JPJ) as the Road Safety Icon for his contributions ...
MPRC, Pusat Media & Perhubungan Awam
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Guidelines for the Use of Synthetic Fluid Dust Control Palliatives on Unpaved Roads [PDF]

, 2017
The amount of small soil particles, dust, lost from typical unpaved roads to fugitive dust is staggering. A 1 km stretch of unpaved road can contribute over 2400 kg of dust to the atmosphere (4.2 ton/mile) in a typical 3-month summer season.
Barnes, David, Connor, Billy
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source