Results 61 to 70 of about 1,196,320 (300)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Multifaceted sensor-based approach for road quality assessment in the Indian road scenario

open access: yesJournal of Road Engineering
This study aims to explore the feasibility of conducting supervised classification of road barriers in a practical context through the utilization of diverse data collection methods.
Anupama Jawale, Amiya Kumar Tripathy
doaj   +1 more source

Towards a Distributed Quantum Computing Ecosystem

open access: yes, 2020
The Quantum Internet, by enabling quantum communications among remote quantum nodes, is a network capable of supporting functionalities with no direct counterpart in the classical world.
Cacciapuoti, Angela Sara   +2 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

Pavement damage decay performance of ordinary national and provincial trunk lines

open access: yesJournal of Highway and Transportation Research and Development
To overcome the limitations inherent in traditional road network-level models for predicting pavement damage decay on ordinary national and provincial trunk lines, this investigation draws on comprehensive detection and evaluation data from A province in
Jianguo Rong   +3 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Analysis of Fume Enrichment Methods and Release Patterns of Plant-Mixed Asphalt Mixtures

open access: yesJournal of Highway and Transportation Research and Development
The disorderly emission and poor treatment effect of asphalt mixture fume in asphalt mixing stations have caused huge harm to the natural environment and human health.
Tengfei Nian   +4 more
doaj   +1 more source

Demonstrations for Children of All Age- The Cork Canon [PDF]

open access: yes, 1999
Demonstrations are one of the most useful techniques for teaching science to anyone, regardless of age. Demonstrations attract attention and normally make the observer want to learn more about what is happening. This paper reports on The Cork Cannon, one
Thornton, S.
core   +1 more source

Effectiveness of Ring Roads in Reducing Traffic Congestion in Cities for Long Run: Big Almaty Ring Road Case Study [PDF]

open access: yes, 2019
It is common to increase road capacity by constructing ring roads to reduce traffic congestion in city areas, although this is often found to be ineffective in the long run.
Arndt, Wulf-Holger   +3 more
core   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

open access: yesAging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

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