Results 61 to 70 of about 1,793,599 (278)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Evaluation of road performance and micro-mechanism analysis of bentonite plastic concrete subgrade

Materials Research Express
This study evaluated the performance of bentonite plasticized concrete with good deformation coordination as a road base material, to address the poor deformation coordination of rigid base layers in roads.
Zhang Guoming, Liang Xiaolin, Zhang Zenghui, Zhu Xincong, Lv Min, Bao Guiyong, Yang Jiacai   +6 more
doaj   +1 more source

Intelligent imaging system for optimal night time driving [PDF]

, 2019
In the recent era, vehicles become a need of public. According to Statistic Portal, in year 2018 alone, more than 81 million vehicles were sold. This results in a large number of vehicles commuting on roads, thus increases the risks of road users.
Hui Ling, Chua, Huong, Audrey
core  

Hardware-in-the-loop simulation of magnetorheological dampers for vehicle suspension systems

, 2007
Magnetorheological (MR) fluids provide an elegant means to enhance vibration control in primary vehicle suspensions. Such fluids can rapidly modify their flow characteristics in response to a magnetic field, so they can be used to create semi-active ...
Batterbee, D.C., Sims, N.D.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

AI-Driven Comprehensive SERS-LFIA System: Improving Virus Automated Diagnostics Through SERS Image Recognition and Deep Learning

Biosensors
Highly infectious and pathogenic viruses seriously threaten global public health, underscoring the need for rapid and accurate diagnostic methods to effectively manage and control outbreaks.
Shuai Zhao, Meimei Xu, Chenglong Lin, Weida Zhang, Dan Li, Yusi Peng, Masaki Tanemura, Yong Yang   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Study on Composition Design and Performance Characteristics of Warm-Mixed Rubber–Asphalt Mixture for Cold-Region Stress Absorption Layers

Buildings
Reflection cracks significantly compromise the service life of half-rigid asphalt pavements in cold regions. This study introduces SAKIII warm-mixed rubber–asphalt mixture (SAKIII WMRA Mix) as a stress absorption layer to address this issue.
Rui Pan, Jifeng Chang, Yu Chen
doaj   +1 more source

Mechanical Properties of Sandstone Cement-Stabilized Macadam

Applied Sciences, 2019
Application of sandstone in cement-stabilized macadam (CSM) is an effective way to utilize sandstone. To determine the feasibility of using sandstone as a CSM aggregate, a series of experimental investigations, such as unconfined compressive strength ...
Qiang Du, Ting Pan, Jing Lv, Jie Zhou, Qingwei Ma, Qiang Sun   +5 more
doaj   +1 more source

A Road Accident [PDF]

, 2010
Shel ko shares his experience of a serious road accident in which the truck he was driving overturned and plunged from the road into a river.The fifty one audio and nine video files in this collection include: villages’ life stories, circle-dancing ...
G.yu lha
core