Results 51 to 60 of about 3,477,162 (301)
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Road safety benefits of intelligent speed adaptation for Australia [PDF]
, 2011 Intelligent Speed Adaptation (ISA) refers to in-vehicle technology systems which assist drivers to keep to or below the speed limit. In 2009-2010 the NSW Centre for Road Safety conducted the NSW ISA Trial which was the largest road safety technology ...
Woolley, J. +9 more
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Policing of road safety in Oman: Perceptions and beliefs of traffic police officers [PDF]
, 2015 With increasing motorisation, road safety has become a major concern within Oman. Internationally, traffic policing plays a major role in improving road safety.
Armstrong, Kerry Ann +3 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source
Australian Road Safety Equipment Certification in Crisis? [PDF]
, 2009 Recent changes to the Australian standard setting and certification system threaten to undermine consumer confidence and certainty in safety products such as helmets and child restraints.
Tom Gibson
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Community Attitudes To Road Safety, 1993
, 2019 This study is the seventh in a series of similar national studies since 1986. It was conducted for the Federal Office of Road Safety to monitor community attitudes to various aspects of road safety.
Adams, Kathryn +1 more
core +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
iRAP Malaysia training course : decade of action for road safety [PDF]
, 2011 The International Road Assessment Program (iRAP) is a not-for-profit organisation that works in partnership with governments and non-government organisations in all parts of the world to make roads safe.
Armstrong, Kerry Ann +4 more
core +1 more source
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source