Results 61 to 70 of about 1,499,547 (353)

Contact Model of Revolute Joint with Clearance Based on Fractal Theory

Chinese Journal of Mechanical Engineering, 2018
The contact stiffness of a mechanical bonding surface is an important parameter in determining the normal and radial contact force. To improve the calculation accuracy of the contact force model, the surface roughness of the bonding surface and the ...
Shi-Hua Li, Xue-Yan Han, Jun-Qi Wang, Jing Sun, Fu-Juan Li   +4 more
doaj   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Extending Driving Vision Based on Image Mosaic Technique

MATEC Web of Conferences, 2017
Car cameras have been used extensively to assist driving by make driving visible. However, due to the limitation of the Angle of View (AoV), the dead zone still exists, which is a primary origin of car accidents.
Chen Deng, Zhang Yanduo, Wei Wei, Li Xiaolin, Zhou Huabing, Zhu Rui, Lu Tao, Li Xun, Xu Haijiao, Peng Li   +9 more
doaj   +1 more source

Topological Map Construction Based on Region Dynamic Growing and Map Representation Method

Applied Sciences, 2019
In the human⁻machine interactive scene of the service robot, obstacle information and destination information are both required, and both kinds of information need to be saved and used at the same time.
Fei Wang, Yuqiang Liu, Ling Xiao, Chengdong Wu, Hao Chu   +4 more
doaj   +1 more source

Type Synthesis of Fully Decoupled Three Translational Parallel Mechanism with Closed-Loop Units and High Stiffness

Chinese Journal of Mechanical Engineering, 2023
In order to solve the problem of weak stiffness of the existing fully decoupled parallel mechanism, a new synthesis method of fully decoupled three translational (3T) parallel mechanisms (PMs) with closed-loop units and high stiffness is proposed based ...
Shihua Li, Sen Wang, Haoran Li, Yongjie Wang, Shuang Chen   +4 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Open-loop position control of a polymer cable–driven parallel robot via a viscoelastic cable model for high payload workspaces

Advances in Mechanical Engineering, 2017
A polymer cable–driven parallel robot has a wide range of potential industrial applications by virtue of its light actuator dynamics, high payload capability, and large workspace. However, due to a viscoelastic behavior of polymer cable and difficulty in
Jinlong Piao, XueJun Jin, Jinwoo Jung, Eunpyo Choi, Jong-Oh Park, Chang-Sei Kim   +5 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Trends and challenges in robot manipulation

Science, 2019
Hand it to you Our ability to grab, hold, and manipulate objects involves our dexterous hands, our sense of touch, and feedback from our eyes and muscles that allows us to maintain a controlled grip.
A. Billard, D. Kragic
semanticscholar   +1 more source