Results 51 to 60 of about 134,994 (267)
Contact Model of Revolute Joint with Clearance Based on Fractal Theory
Chinese Journal of Mechanical Engineering, 2018 The contact stiffness of a mechanical bonding surface is an important parameter in determining the normal and radial contact force. To improve the calculation accuracy of the contact force model, the surface roughness of the bonding surface and the ...
Shi-Hua Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Advances in Mechanical Engineering, 2017 A polymer cable–driven parallel robot has a wide range of potential industrial applications by virtue of its light actuator dynamics, high payload capability, and large workspace. However, due to a viscoelastic behavior of polymer cable and difficulty in
Jinlong Piao +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Scientific ReportsThis paper addresses current issues in existing joint tracking and motion recognition algorithms for Human Pose Estimation. It proposes a solution using the Numerical Discriminator Generative Adversarial Network (ND_GAN) to improve the performance of ...
Kyoung-Geun Cho +9 more
doaj +1 more source
Extending Driving Vision Based on Image Mosaic Technique
MATEC Web of Conferences, 2017 Car cameras have been used extensively to assist driving by make driving visible. However, due to the limitation of the Angle of View (AoV), the dead zone still exists, which is a primary origin of car accidents.
Chen Deng +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Topological Map Construction Based on Region Dynamic Growing and Map Representation Method
Applied Sciences, 2019 In the human⁻machine interactive scene of the service robot, obstacle information and destination information are both required, and both kinds of information need to be saved and used at the same time.
Fei Wang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source