Results 11 to 20 of about 140 (138)

Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness

open access: yesThe FASEB Journal, Volume 37, Issue 11, November 2023., 2023
The Toxoplasma “pseudo” ceramide synthase (TgCerS2) defines a novel apicomplexan class of these essential enzymes. Abstract Toxoplasma gondii is an obligate, intracellular apicomplexan protozoan parasite of both humans and animals that can cause fetal damage and abortion and severe disease in the immunosuppressed.
Zisis Koutsogiannis   +6 more
wiley   +1 more source

Optimizing VLP production in gene therapy: Opportunities and challenges for in silico modeling

open access: yesBiotechnology Journal, Volume 18, Issue 7, July 2023., 2023
Graphical Abstract and Lay Summary Abstract Over the past decades, virus‐like particle (VLP)‐based gene therapy (GT) evolved as a promising approach to cure inherited diseases or cancer. Tremendous costs due to inefficient production processes remain one of the key challenges despite considerable efforts to improve titers.
Leopold Zehetner   +5 more
wiley   +1 more source

Delayed cortical thinning in children and adolescents with prenatal alcohol exposure

open access: yesAlcohol, Clinical and Experimental Research, Volume 47, Issue 7, Page 1312-1326, July 2023., 2023
Prenatal alcohol exposure (PAE) is associated with cross‐sectional brain anomalies, and emerging data suggest atypical trajectories of cortical maturation. This longitudinal study adds to the existing literature by demonstrating that youth age 8‐17 with PAE have reduced age‐related cortical thickness change compared to non‐exposed Comparisons as well ...
Blake A. Gimbel   +11 more
wiley   +1 more source

Gratifications in change of privacy? The response of four consumers' generational cohorts toward facial recognition technology in retail settings

open access: yesJournal of Consumer Behaviour, Volume 22, Issue 2, Page 288-299, March/April 2023., 2023
Abstract New technologies enable retailers to collect large amounts of information about consumers, which might lead to ethical issues and risks of individuals' privacy loss. However, consumers might choose to disclose information to retailers when they perceive that the information would generate more benefits for themselves rather than for the ...
Eleonora Pantano   +2 more
wiley   +1 more source

Depicting environmental gradients from Malaise trap samples: Is ethanol‐based DNA metabarcoding enough?

open access: yesInsect Conservation and Diversity, Volume 16, Issue 1, Page 47-64, January 2023., 2023
We conducted metabarcoding on tissue‐based DNA and on ethanol‐based DNA of the same Malaise trap samples. Then, we compared results in regard to the representation of environmental gradients. The tissue‐based DNA depicted clear environmental gradients.
Caroline Chimeno   +7 more
wiley   +1 more source

Cost‐Effectiveness of Insertable Cardiac Monitor in Unexplained Syncope—Based on Real‐World Data From China

open access: yesJournal of Arrhythmia, Volume 41, Issue 5, October 2025.
This analysis suggests that ICM is a cost‐effective strategy, versus conventional testing, for the diagnosis of unexplained syncope in China, and supports wider uptake of the technology. ABSTRACT Background The use of an insertable cardiac monitor (ICM) is recommended to help diagnose patients with unexplained syncope.
Yijia Tang   +6 more
wiley   +1 more source

The Paragenital Organ of Stylopidae (Insecta: Strepsiptera) and the Functional Incorporation of the Secondary Larval Exuvia

open access: yesJournal of Morphology, Volume 286, Issue 9, September 2025.
In the insect order Strepsiptera, we identified a paragenital organ in the family Stylopidae that serves as a secondary genital organ for traumatic insemination. We show that the cuticle at the penetration sites is thickened in all species studied, relative to control sites.
Kenny Jandausch   +6 more
wiley   +1 more source

Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 4, April 2025.
Lifelong medication in patients with chronic diseases compromises treatment adherence, therapeutic outcomes, and quality of life. The bioinspired 4D‐printed polypill self‐deploys upon ingestion, constricting passage through the pylorus while at the same time providing sustained drug release, serving as drug delivery platform with applications in both ...
Konstantina Chachlioutaki   +9 more
wiley   +1 more source

Astrocytic determinant of the fate of long‐term memory

open access: yesGlia, Volume 73, Issue 2, Page 309-329, February 2025.
Main Points Opposing astrocyte manipulations cause fear‐like states or reduce fear. Astrocytes, at the moment of an experience, determine the long‐term memory fate. Astro‐ChR2 suppresses memory consolidation, while Astro‐ArchT inhibits remote memory decay.
Hiroki Yamao, Ko Matsui
wiley   +1 more source

Ecological interactions in glacier environments: a review of studies on a model Alpine glacier

open access: yesBiological Reviews, Volume 100, Issue 1, Page 227-244, February 2025.
ABSTRACT Glaciers host a variety of cold‐adapted taxa, many of which have not yet been described. Interactions among glacier organisms are even less clear. Understanding ecological interactions is crucial to unravelling the functioning of glacier ecosystems, particularly in light of current glacier retreat.
Arianna Crosta   +15 more
wiley   +1 more source

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