Results 71 to 80 of about 974,674 (296)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Resource-Saving Customizable Pipeline Network Architecture for Multi-Signal Processing in Edge Devices

open access: yesSensors, 2022
With the development of the information age, the importance of edge computing has been highlighted in industrial site monitoring, health management, and fault diagnosis.
Ping Song   +7 more
doaj   +1 more source

A review of mobile robots: Concepts, methods, theoretical framework, and applications

open access: yesInternational Journal of Advanced Robotic Systems, 2019
Humanoid robots, unmanned rovers, entertainment pets, drones, and so on are great examples of mobile robots. They can be distinguished from other robots by their ability to move autonomously, with enough intelligence to react and make decisions based on ...
F. Rubio, F. Valero, C. Llopis-Albert
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Microstructure and mechanical property of laser-welded aluminum alloy/steel joints by using AlSiCu + nano Mo powder

open access: yesHanjie xuebao
To improve the mechanical properties of aluminum alloy and steel joints and suppress the excessive formation of brittle intermetallic compounds (IMCs) at the interface during laser welding, AlSiCu alloy powder and composite powder prepared by AlSiCu + Mo
Min LEI   +6 more
doaj   +1 more source

Robotic Endoscopy [PDF]

open access: yesVisceral Medicine, 2018
Endoscopes extend the eyes of the physician into the patient's body. They are widely used in gastrointestinal (GI) diagnostics and minimally invasive surgery. Endoscopes can be classified into 3 types: rigid, flexible, and capsule endoscopes. Rigid and flexible endoscopes are traditionally held and manipulated by the physician to visualize the region ...
Zheng, Li, Philip Wai-Yan, Chiu
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Design and Analysis of a High-Speed Slotless Permanent Magnet Synchronous Motor Considering Air-Gap Airflow

open access: yesActuators
The air-gap airflow significantly influences the performance of high-speed slotless permanent magnet synchronous motors (HSSPMSM), yet this critical factor is frequently overlooked during the design phase, resulting in performance deviations.
Hong-Jin Hu   +4 more
doaj   +1 more source

Joint-Space Characterization of a Medical Parallel Robot Based on a Dual Quaternion Representation of SE(3)

open access: yesMathematics, 2020
The paper proposes a mathematical method for redefining motion parameterizations based on the joint-space representation of parallel robots. The study parameters of SE(3) are used to describe the robot kinematic chains, but, rather than directly ...
Iosif Birlescu   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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