Results 71 to 80 of about 3,738,279 (288)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Structured Singular Value Control With General Two‐Degree‐of‐Freedom Feedback Loop Factorisation for Single‐Input Single‐Output Systems

open access: yesThe Journal of Engineering
General two‐degree‐of‐freedom feedback loop factorisation for single‐input single‐output systems applied to oscillating plants with time delay, periodic changes of the controlled plant parameters and astatism using the D‐K iteration and algebraic ...
Marek Dlapa
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Robust Longitudinal Aircraft- Control Based on an Adaptive Fuzzy-Logic Algorithm

open access: yesSultan Qaboos University Journal for Science, 2002
To study the aircraft response to a fast pull-up manoeuvre, a short period approximation of the longitudinal model is considered. The model is highly nonlinear and includes parametric uncertainties.
Abdel- Latif Elshafei
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A novel robust generalized backstepping controlling method for a class of nonlinear systems

open access: yesCogent Engineering, 2017
This study is aimed at introducing a new robust control strategy in developed backstepping method designed for a special class of nonlinear systems, which does not require any information on the upper bound of parametric uncertainties.
Malek Ghanavati   +4 more
doaj   +1 more source

Robust Task Space Trajectory Tracking Control of Robotic Manipulators

open access: yesInternational Journal of Applied Mechanics and Engineering, 2016
This work deals with the problem of the accurate task space trajectory tracking subject to finite-time convergence. Kinematic and dynamic equations of a redundant manipulator are assumed to be uncertain.
M. Galicki
doaj   +1 more source

Robust predictive feedback control for constrained systems [PDF]

open access: yes, 2004
A new method for the design of predictive controllers for SISO systems is presented. The proposed technique allows uncertainties and constraints to be concluded in the design of the control law. The goal is to design, at each sample instant, a predictive
Giovanini, Leonardo, Grimble, Michael
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Robust virtual‐vector model predictive control of permanent‐magnet motor considering D‐Q axis inductance parameter uncertainty

open access: yesIET Electric Power Applications
To suppress parameter mismatch and improve the output performance of model predictive control (MPC), a new robust virtual‐vector MPC strategy is proposed for a five‐phase permanent‐magnet motor in this study.
Xingke An   +3 more
doaj   +1 more source

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