Results 101 to 110 of about 4,199,571 (295)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Iron-crosslinked Rososome with robust stability and high drug loading for synergistic cancer therapy. [PDF]

J Control Release, 2021
Xue X, Ricci M, Qu H, Lindstrom A, Zhang D, Wu H, Lin TY, Li Y.   +7 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Architecting Hierarchical WO₃ Agglomerates Assembled With Straight and Parallel Aligned Nanoribbons Enabling High Capacity and Robust Stability of Lithium Storage. [PDF]

Front Chem, 2021
Dong X, Liu Y, Zhu S, Ou Y, Zhang X, Lan W, Guo H, Zhang C, Liu Z, Ju S, Miao Y, Zhang Y, Li H.   +12 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Highly Efficient Computationally Derived Novel Metagenome α-Amylase With Robust Stability Under Extreme Denaturing Conditions. [PDF]

Front Microbiol, 2021
Ariaeenejad S, Zolfaghari B, Sadeghian Motahar SF, Kavousi K, Maleki M, Roy S, Hosseini Salekdeh G.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deriving High-Energy-Density Polymeric Nitrogen N₁₀ from the Host–Guest ArN₁₀ Compound

Nanomaterials
Discovering stable polymeric nitrogen phases and exploring their properties are crucial for energy storage and conversion, garnering significant attention.
Lulu Liu, Jiacheng Qi, Dinghui Wang, Jie Yuan, Difen Shi, Zhigang Xiong, Ting Ye, Yubei Cai, Lei Zhang   +8 more
doaj   +1 more source

Robust Stabilization of Uncertain Systems

Journal of Mathematical Analysis and Applications, 1995
A controlled system with bounded deterministic uncertainty is described by a differential inclusion. Assuming that a Lyapunov function is known, a differential inclusion, governing the evolution of some subset of admissible controls in order to achieve asymptotic stability is derived.
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source