Results 141 to 150 of about 612,805 (315)
Multi-objective design of robust flight control systems [PDF]
, 2008 A multi–objective evolutionary algorithm is used in the framework of H1 control theory to find the controller gains that minimize a weighted combination of the infinite–norm of the sensitivity function (for disturbance attenuation requirements) and ...
Avanzini, G. +4 more
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Nash Equilibrium and Robust Stability in Dynamic Games: A Small-Gain Perspective [PDF]
This paper develops a novel methodology to study robust stability properties of Nash equilibrium points in dynamic games. Small-gain techniques in modern mathematical control theory are used for the first time to derive conditions guaranteeing uniqueness
Jiang, Zhong-Ping +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Robust Stabilization of Uncertain Systems
Journal of Mathematical Analysis and Applications, 1995 A controlled system with bounded deterministic uncertainty is described by a differential inclusion. Assuming that a Lyapunov function is known, a differential inclusion, governing the evolution of some subset of admissible controls in order to achieve asymptotic stability is derived.
openaire +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Robust Control Rules to Shield Against Indeterminacy [PDF]
We address robustness of inflation targeting rules in a New Keynesian model using two approaches. Firstly we use the Hansen-Sargent method, borrowed from the control theory literature, to design robust rules on the basis of the policymaker playing a game
Paul Levine, Nicoletta Batini
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Computation of stability robustness bounds for discrete-time systems with structured time-varying uncertainty [PDF]
, 2010 This paper is concerned with stability robustness bounds for those systems passing any one of two well known robust stability tests of theory. We explicitly characterize the trade-off between the allowable perturbation size and the associated maximal ...
Chou, Yung-Shan; Lei, Sheng-Kai
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source