Results 71 to 80 of about 4,199,571 (295)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Stability and robust stability of multivariate polynomials
, 1997 An attempt is made towards selection of a class of multivariate polynomials which has the property that polynomials front this class preserve stability in the presence of small coefficient variations.
Ramirez Sosa Moran, M.I. +2 more
core +1 more source
Geometric Interpretation of Frequency Domain Robustness Constraints and Closed-Loop Pole Locations
MathematicsRequirements for robustness and performance in the frequency domain in control theory are usually formulated as constraints on the modulus of complex functions describing the open-loop system, the sensitivity function, and the complementary sensitivity ...
Vesela Karlova-Sergieva
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Robust Stability of Iterative Learning Control Schemes
, 2008 A notion of robust stability is developed for iterative learning control in the context of disturbance attenuation. The size of the unmodelled dynamics is captured via a gap distance, which in turn is related to the standard H2 gap metric, and the ...
French, Mark
core
Robust Stability for Impulsive Systems With Polytope Uncertainties
IEEE Access, 2019 This paper is concerned with robust stability for impulsive systems with polytope uncertainties. At first, the stability for impulsive systems without uncertainties is addressed by employing a Lyapunov-like functional.
Hanyong Shao, Wenjing Wang
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source