Results 101 to 110 of about 567,669 (271)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
PLoS Computational Biology, 2013 Gene regulatory networks show robustness to perturbations. Previous works identified robustness as an emergent property of gene network evolution but the underlying molecular mechanisms are poorly understood.
Mario Pujato +3 more
doaj +1 more source
High-dimensional quantum state transfer in a noisy network environment
, 2015 We propose and analyze an efficient high-dimensional quantum state transfer protocol in an XX coupling spin network with a hypercube structure or chain structure. Under free spin wave approximation, unitary evolution results in a perfect high-dimensional
Li, Jun-Lin, Long, Gui-Lu, Qin, Wei
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Méthodes de surclassement et analyse de robustesse [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2001 Outranking methods and robustness analysis. The introduction gives the arguments on which the choice of outranking methods is based: application domain, existence of a software, lack of works on the robustness of outranking methods.
Ben-Mena S.
doaj
Evolution of Robust Developmental Neural Networks [PDF]
, 2004 We present the first evolved solutions to a computational task within the Neuronal Organism Evolution model (Norgev) of artificial neural network development. These networks display a remarkable robustness to external noise sources, and can regrow to functionality when severely damaged. In this framework, we evolved a doubling of network functionality (
Hampton, Alan N., Adami, Chris
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Biological Robustness: Paradigms, Mechanisms, and Systems Principles
Frontiers in Genetics, 2012 Robustness has been studied through the analysis of data sets, simulations, and a variety of experimental techniques that each have their own limitations but together confirm the ubiquity of biological robustness.
James Michael Whitacre
doaj +1 more source
ES Is More Than Just a Traditional Finite-Difference Approximator
, 2018 An evolution strategy (ES) variant based on a simplification of a natural evolution strategy recently attracted attention because it performs surprisingly well in challenging deep reinforcement learning domains.
Chen, Jay +3 more
core +1 more source