Results 11 to 20 of about 567,669 (271)
Evolution of Robustness in Digital Organisms [PDF]
Artificial Life, 2004 We study the evolution of robustness in digital organisms adapting to a high mutation rate. As genomes adjust to the harsh mutational environment, the mean effect of single mutations decreases, up until the point where a sizable fraction (up to 30% in many cases) of the mutations are neutral.
Edlund, Jeffrey A., Adami, Christoph
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Parasites lead to evolution of robustness against gene loss in host signaling networks [PDF]
Molecular Systems Biology, 2008 Many biological networks can maintain their function against single gene loss. However, the evolutionary mechanisms responsible for such robustness remain unclear.
Marcel Salathé, Orkun S Soyer
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Revisiting robustness and evolvability: evolution in weighted genotype spaces. [PDF]
PLoS ONE, 2014 Robustness and evolvability are highly intertwined properties of biological systems. The relationship between these properties determines how biological systems are able to withstand mutations and show variation in response to them. Computational studies
Raghavendran Partha, Karthik Raman
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Evolution of robustness and cellular stochasticity of gene expression. [PDF]
PLoS Biology, 2013 Gene expression varies widely in cells with the same genotype and environment. Predicting the patterns of stochastic cellular fluctuations remains an unsolved challenge.
Steven A Frank
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Robust evolution system for numerical relativity [PDF]
Physical Review D, 1999 11 pages, 4 figures; figure ...
Arbona, A. +3 more
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Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. [PDF]
PLoS ONE, 2010 Gene inactivation often has little or no apparent consequence for the phenotype of an organism. This property-enetic (or mutational) robustness-is pervasive, and has important implications for disease and evolution, but is not well understood.
Ben Lehner
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Does evolution design robust food webs ? [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2019 Theoretical works that use a dynamical approach to study the ability of ecological communities to resist perturbations are largely based on randomly generated ecosystem structures. In contrast, we propose here to asses the robustness of food webs drawn from ecological and evolutionary processes with the use of community evolution models.
Annasawmy, Pavanee +8 more
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Developmental Evolution: Getting Robust About Robustness [PDF]
Current Biology, 2002 In the context of development, a process is robust if it can proceed normally despite the enormous capacity for perturbation inherent in all biological systems. A new mode of theoretical modeling of genetic networks holds great promise for increasing our understanding of both the quantitative mechanisms of robustness and its evolutionary impact.
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Punctuated evolution and robustness in morphogenesis [PDF]
Biosystems, 2014 This paper presents an analytic approach to the pattern stability and evolution problem in morphogenesis. The approach used here is based on the ideas from the gene and neural network theory. We assume that gene networks contain a number of small groups of genes (called hubs) controlling morphogenesis process.
Grigoriev, D. +3 more
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The evolution and mutational robustness of chromatin accessibility in Drosophila
Genome Biology, 2023 Background The evolution of genomic regulatory regions plays a critical role in shaping the diversity of life. While this process is primarily sequence-dependent, the enormous complexity of biological systems complicates the understanding of the factors ...
Samuel Khodursky +7 more
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