Results 21 to 30 of about 548,676 (308)

Revisiting robustness and evolvability: evolution in weighted genotype spaces. [PDF]

PLoS ONE, 2014
Robustness and evolvability are highly intertwined properties of biological systems. The relationship between these properties determines how biological systems are able to withstand mutations and show variation in response to them. Computational studies
Raghavendran Partha, Karthik Raman
doaj   +1 more source

Evolution of robustness and cellular stochasticity of gene expression. [PDF]

PLoS Biology, 2013
Gene expression varies widely in cells with the same genotype and environment. Predicting the patterns of stochastic cellular fluctuations remains an unsolved challenge.
Steven A Frank
doaj   +1 more source

Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. [PDF]

PLoS ONE, 2010
Gene inactivation often has little or no apparent consequence for the phenotype of an organism. This property-enetic (or mutational) robustness-is pervasive, and has important implications for disease and evolution, but is not well understood.
Ben Lehner
doaj   +1 more source

Degeneracy: a link between evolvability, robustness and complexity in biological systems [PDF]

, 2010
A full accounting of biological robustness remains elusive; both in terms of the mechanisms by which robustness is achieved and the forces that have caused robustness to grow over evolutionary time.
A Force, A Wagner, A Wagner, A Wagner, A Wagner, A Wagner, B Edmonds, B Guo, B Walker, C Adami, C Darwin, CO Wilke, CR Shalizi, CS Holling, DB Wake, DW McShea, EL Berlow, F Rothlauf, G Tononi, G Tononi, GC Conant, GM Edelman, GP Wagner, H Kitano, H Kitano, HW Ma, J Moore, J Reisinger, J Stelling, J Visser, James M Whitacre, JD Knowles, JDJ Han, JM Carlson, JM Carlson, JM Whitacre, JM Whitacre, JP Crutchfield, JP Crutchfield, KH Wolfe, LW Ancel, M Aldana, M Gell-Mann, M Kirschner, MA Huynen, MC Cowperthwaite, ME Csete, MS Granovetter, P Csermely, R Dawkins, R Tanaka, RE Keller, RM Hazen, S Carpenter, S Ciliberti, S Ohno, SA Newman, T Kitami, T Smith, T Yu, U Sauer, VK Vassilev, W Banzhaf   +62 more
core   +5 more sources

Recombination drives the evolution of mutational robustness [PDF]

Current Opinion in Systems Biology, 2019
Recombination can impose fitness costs as beneficial parental combinations of alleles are broken apart, a phenomenon known as recombination load. Computational models suggest that populations may evolve a reduced recombination load by reducing either the likelihood of recombination events (bring interacting loci in physical proximity) or the strength ...
Sonia Singhal, Shawn M. Gomez, Christina L. Burch   +2 more
openalex   +4 more sources

PERSPECTIVE: EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS [PDF]

Evolution, 2003
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness.
de Visser, J.A.G.M., Hermisson, J., Wagner, G.P., Ancel Meyers, L., Bagheri-Chaichian, H., Blanchard, J.L., Chao, L., Cheverud, J.M., Elena, S.F., Fontana, W., Gibson, G., Hansen, T.F., Krakauer, D., Lewontin, R.C., Ofria, C., Rice, S.H., von Dassow, G., Wagner, A., Whitlock, M.C.   +18 more
openaire   +4 more sources

Robustness of adiabatic quantum computation [PDF]

, 2001
We study the fault tolerance of quantum computation by adiabatic evolution, a quantum algorithm for solving various combinatorial search problems. We describe an inherent robustness of adiabatic computation against two kinds of errors, unitary control ...
Andrew M. Childs, E. Farhi, E.B. Davies, E.B. Davies, Edward Farhi, F. Barahona, J. Brooke, John Preskill, P. Zanardi, R. Dümcke, S. Lloyd, T. Kadowaki, T. Kato, W. Ogburn   +13 more
core   +2 more sources

Developmental Evolution: Getting Robust About Robustness [PDF]

Current Biology, 2002
In the context of development, a process is robust if it can proceed normally despite the enormous capacity for perturbation inherent in all biological systems. A new mode of theoretical modeling of genetic networks holds great promise for increasing our understanding of both the quantitative mechanisms of robustness and its evolutionary impact.
openaire   +3 more sources

Robust evolution system for numerical relativity [PDF]

Physical Review D, 1999
11 pages, 4 figures; figure ...
Arbona, A., Bona, C., Masso, J., Stela, J.   +3 more
openaire   +2 more sources

EvoRSR: an integrated system for exploring evolution of RNA structural robustness

BMC Bioinformatics, 2009
Background Robustness, maintaining a constant phenotype despite perturbations, is a fundamental property of biological systems that is incorporated at various levels of biological complexity.
Ni Ming, Shu Wenjie, Bo Xiaochen, Zheng Zhiqiang, Wang Shengqi   +4 more
doaj   +1 more source