Results 21 to 30 of about 99,185 (278)
Evolution under fluctuating environments explains observed robustness in metabolic networks. [PDF]
PLoS Computational Biology, 2010 A high level of robustness against gene deletion is observed in many organisms. However, it is still not clear which biochemical features underline this robustness and how these are acquired during evolution.
Orkun S Soyer, Thomas Pfeiffer
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Punctuated evolution and robustness in morphogenesis [PDF]
Biosystems, 2014 This paper presents an analytic approach to the pattern stability and evolution problem in morphogenesis. The approach used here is based on the ideas from the gene and neural network theory. We assume that gene networks contain a number of small groups of genes (called hubs) controlling morphogenesis process.
Andreas Weber +3 more
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Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations? [PDF]
PLoS Computational Biology, 2010 Lethal mutagenesis is a promising new antiviral therapy that kills a virus by raising its mutation rate. One potential shortcoming of lethal mutagenesis is that viruses may resist the treatment by evolving genomes with increased robustness to mutations ...
Eamon B O'Dea +2 more
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Revisiting robustness and evolvability: evolution in weighted genotype spaces. [PDF]
PLoS ONE, 2014 Robustness and evolvability are highly intertwined properties of biological systems. The relationship between these properties determines how biological systems are able to withstand mutations and show variation in response to them. Computational studies
Raghavendran Partha, Karthik Raman
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Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. [PDF]
PLoS ONE, 2010 Gene inactivation often has little or no apparent consequence for the phenotype of an organism. This property-enetic (or mutational) robustness-is pervasive, and has important implications for disease and evolution, but is not well understood.
Ben Lehner
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A Role for Selection in the Evolution of Genetic Robustness.
PLoS Biology, 2005 doaj +3 more sources
Robust evolution system for numerical relativity [PDF]
Physical Review D, 1999 11 pages, 4 figures; figure ...
J. Stela +3 more
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Developmental Evolution: Getting Robust About Robustness [PDF]
Current Biology, 2002 In the context of development, a process is robust if it can proceed normally despite the enormous capacity for perturbation inherent in all biological systems. A new mode of theoretical modeling of genetic networks holds great promise for increasing our understanding of both the quantitative mechanisms of robustness and its evolutionary impact.
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Recombination drives the evolution of mutational robustness [PDF]
Current Opinion in Systems Biology, 2019 Recombination can impose fitness costs as beneficial parental combinations of alleles are broken apart, a phenomenon known as recombination load. Computational models suggest that populations may evolve a reduced recombination load by reducing either the likelihood of recombination events (bring interacting loci in physical proximity) or the strength ...
Shawn M. Gomez +2 more
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Recombination and the evolution of mutational robustness
Journal of Theoretical Biology, 2006 Mutational robustness is the degree to which a phenotype, such as fitness, is resistant to mutational perturbations. Since most of these perturbations will tend to reduce fitness, robustness provides an immediate benefit for the mutated individual. However, robust systems decay due to the accumulation of deleterious mutations that would otherwise have ...
Gardner, A, Kalinka, A
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