Results 61 to 70 of about 99,185 (278)
Evolvability and Robustness in Populations of RNA Virus Φ6
Frontiers in Microbiology, 2014 Microbes can respond quickly to environmental disturbances through adaptation. However, processes determining the constraints on this adaptation are not well understood.
Daniel eGoldhill +3 more
doaj +1 more source
A robust optimization method based on previous optimization knowledge
Zhongguo Jianchuan Yanjiu, 2022 ObjectivesAs solving the robust optimization (RO) problem with interval uncertainty is unduly time-consuming when the nested differential evolution algorithm is directly used, a new RO design method is proposed.MethodsIn the proposed method, individuals'
Guochen LYU +3 more
doaj +1 more source
On Robust Evolution of Digital Hardware [PDF]
, 2008 In this paper we investigate whether multi-objective evolution of digital hardware components has advantages over single-objective evolution in terms of convergence and robustness. To that end, we experimentally compare a standard genetic algorithm to several multi-objective optimizers on a set of test problems.
Bertrand Defo +3 more
openaire +2 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Epistasis as a determinant of the HIV-1 protease's robustness to mutation. [PDF]
PLoS ONE, 2014 The robustness of phenotypes to mutation is critical to protein evolution; robustness may be an adaptive trait if it promotes evolution. We hypothesised that native proteins subjected to natural selection in vivo should be more robust than proteins ...
Elena Capel +2 more
doaj +1 more source
The role of mutational robustness in RNA virus evolution [PDF]
Nature Reviews Microbiology, 2013 RNA viruses face dynamic environments and are masters at adaptation. During their short 'lifespans', they must surmount multiple physical, anatomical and immunological challenges. Central to their adaptative capacity is the enormous genetic diversity that characterizes RNA virus populations.
Lauring, Adam S +2 more
openaire +5 more sources
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Evolving robust gene regulatory networks. [PDF]
PLoS ONE, 2015 Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'.
Nasimul Noman +3 more
doaj +1 more source
Mitochondrial fatty acid oxidation is stimulated by red light irradiation
FEBS Letters, EarlyView.Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera +4 more
wiley +1 more source
Robustness of the long-term nonlinear evolution of global sea surface temperature trend
Geoscience Letters, 2022 The multi-scale variability of global sea surface temperature (GSST), which is often dominated by secular trends, significantly impacts global and regional climate change. Previous studies were mainly carried out under linear assumptions.
Zhenhao Xu +5 more
doaj +1 more source