Results 71 to 80 of about 562,963 (309)

A robust optimization method based on previous optimization knowledge

open access: yesZhongguo Jianchuan Yanjiu, 2022
ObjectivesAs solving the robust optimization (RO) problem with interval uncertainty is unduly time-consuming when the nested differential evolution algorithm is directly used, a new RO design method is proposed.MethodsIn the proposed method, individuals'
Guochen LYU   +3 more
doaj   +1 more source

Accelerated adiabatic quantum gates: optimizing speed versus robustness

open access: yes, 2019
We develop new protocols for high-fidelity single qubit gates that exploit and extend theoretical ideas for accelerated adiabatic evolution. Our protocols are compatible with qubit architectures with highly isolated logical states, where traditional ...
Clerk, A., Ribeiro, H.
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Evolution of Canalizing Boolean Networks

open access: yes, 2007
Boolean networks with canalizing functions are used to model gene regulatory networks. In order to learn how such networks may behave under evolutionary forces, we simulate the evolution of a single Boolean network by means of an adaptive walk, which ...
A. Szejka   +19 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Epistasis as a determinant of the HIV-1 protease's robustness to mutation. [PDF]

open access: yesPLoS ONE, 2014
The robustness of phenotypes to mutation is critical to protein evolution; robustness may be an adaptive trait if it promotes evolution. We hypothesised that native proteins subjected to natural selection in vivo should be more robust than proteins ...
Elena Capel   +2 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Evolving robust gene regulatory networks. [PDF]

open access: yesPLoS ONE, 2015
Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'.
Nasimul Noman   +3 more
doaj   +1 more source

Equation of motion for multiqubit entanglement in multiple independent noisy channels

open access: yes, 2012
We investigate the possibility and conditions to factorize the entanglement evolution of a multiqubit system passing through multi-sided noisy channels. By means of a lower bound of concurrence (LBC) as entanglement measure, we derive an explicit formula
Greenberger D M   +7 more
core   +1 more source

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