Results 141 to 150 of about 165,159 (247)

Determination of Upper Reference Limit for High-Sensitivity Troponin T in the Healthy Population of Balochistan

Journal of Islamic International Medical College
Objective: To determine the 99th percentile upper reference limit of high-sensitivity cardiac troponin T in the healthy population of North and South Balochistan, Pakistan, with age-and gender- stratification. Study Design: Cross-sectional, Observational.
Sania Khan, Sayed Tanveer Abbas Gilani, Muhammad Zeeshan Rana, Muhammad Zubair, Usman Gulzar, Faiqa Mubeen
doaj  

Diverse configurations of binary asteroids explained by multi-generation satellites. [PDF]

Nat Commun
Dai WY, Cheng B, Huang Y, Jiao Y, Zhou WH, Ren KY, Agrusa H, Jacobson S, Kokubo E, Charnoz S, Yu Y, Baoyin H, Li J.   +12 more
europepmc   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Longitudinal Sigma-Metric Profiling of Two Clinical Chemistry Platforms Using Peer-Group Internal Quality Control. [PDF]

Diagnostics (Basel)
Meyliza I, Aryati A, Marpaung FR.
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

The Evolution of Accelerated Diagnostic Protocols for Suspected Myocardial Infarction. [PDF]

J Clin Med
Hatherley J, Collinson P, Abuzahra T, Khand A.   +3 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Diagnostic utility of basal luteinizing hormone in evaluating central precocious puberty. [PDF]

J Endocr Soc
Ferrari V, Elleri D, Roach J, Crane M, Mitchell RT.   +4 more
europepmc   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Patient-Centric First-in-Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T-Cell Engagers in Multiple Myeloma. [PDF]

Clin Pharmacol Ther
Kraft TE, Marrer-Berger E, Belli S, Haegel H, Schneider A, Giusti AM, Bscheider M, Jacob W, Weisser M, Blanco L, Frances N, Rossmann E, Steiner G, Azpiroz AZ, Paiva B, Martinet L, Fauti T.   +16 more
europepmc   +1 more source