Results 41 to 50 of about 1,132,394 (292)

Modelling of cutting fibrous composite materials: current practice [PDF]

, 2015
Using fibre reinforced polymers (FRP) is increasing across many industries. Although FRP are laid-up in the near-net shape, several cutting operations are necessary to meet quality and dimensional requirements.
Kahwash, Fadi, Maheri, A., Shyha, Islam, Kahwash, F., Shyha, I., Maheri, Alireza   +5 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evaluation of rock cutting performance of diamond segmented frame saw in terms of diamond segment wear [PDF]

, 2021
Diamond segmented frame saws are used to produce slab from natural stone blocks in stone processing plants. Diamond segments welded on flat steel blades are utilized for rock block cutting in frame saws.
Kulaksiz, Seyfi, BAYRAM, FATİH
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A Practical Noise2Noise Denoising Pipeline for High‐Throughput Raman Spectroscopy

Advanced Engineering Materials, EarlyView.
A lightweight and reproducible denoising pipeline for high‐throughput Raman spectroscopy is introduced, based on a 1D convolutional autoencoder trained with a Noise2Noise strategy. Using only repeated short‐exposure acquisitions, the method suppresses stochastic noise without reference spectra, enabling reliable spectral reconstruction while preserving
David Martin‐Calle, Cesar Alvarez‐Llamas, Vincent Motto‐Ros, Christophe Dujardin, Jérémie Margueritat, David Rodney   +5 more
wiley   +1 more source

Fractal Characteristic of Rock Cutting Load Time Series

Discrete Dynamics in Nature and Society, 2014
A test-bed was developed to perform the rock cutting experiments under different cutting conditions. The fractal theory was adopted to investigate the fractal characteristic of cutting load time series and fragment size distribution in rock cutting.
Hongxiang Jiang, Changlong Du, Songyong Liu, Kuidong Gao   +3 more
doaj   +1 more source

Research on numerical drilling technology of mesh-like cutting PDC bit

Energy Reports, 2021
Numerical simulation on rock-breaking and drilling has been developed as a novel technic for designing and performance analyzing of the bit. On basis of theoretical research and experimental test on the mesh-like cutting PDC bit, the numerical model of ...
Chun-Liang Zhang, Ying-Xin Yang, Qing-Liang Qi, Hai-Tao Ren, Jin-Cheng Wang   +4 more
doaj   +1 more source

Leveraging Symbolic Artificial Intelligence and Fuzzy Logic for Materials Science: A Review of Methods, Challenges, and Applications to Scarce and Imperfect Experimental Data

Advanced Engineering Materials, EarlyView.
This article explores the transformative potential of symbolic artificial intelligence (AI) in the field of materials science, particularly in leveraging experimental data. The article presents several symbolic AI models and discusses their applications in materials science.
Ahmed Amrani, Mohamed‐Ali Belloum, Laurence Boudet, Valentin Fouillard, Edwin Friedmann, Guillaume Lacharme, Ali Mahmoud, Jean‐Philippe Poli   +7 more
wiley   +1 more source

Influence of Cutting Angle on Temperature Distribution of Cutter

Shiyou jixie, 2021
The failure of cutter is closely related to cutting temperature, and the formation of cuttings has an impact on the performance and life of cutter. This article builds a rock-breaking mechanics model to conduct numerical simulation analysis on rock ...
Zhang Zaixing, Zhou Qin, Zhang Kai, Li Long, Li Yao   +4 more
doaj  

Experimental investigation of hydrodynamics of melt layer during laser cutting of steel [PDF]

, 2011
In laser cutting process, understanding of hydrodynamics of melt layer is significant, because it is an important factor which controls the final quality. In this work, we observed hydrodynamics of melt layer on kerf front in the case of laser cutting of
Remy Fabbro, Koji Hirano, FABBRO, Rémy, HIRANO, Koji   +3 more
core   +1 more source