Results 51 to 60 of about 382,665 (308)

Influence of Cutting Angle on Temperature Distribution of Cutter

open access: yesShiyou jixie, 2021
The failure of cutter is closely related to cutting temperature, and the formation of cuttings has an impact on the performance and life of cutter. This article builds a rock-breaking mechanics model to conduct numerical simulation analysis on rock ...
Zhang Zaixing   +4 more
doaj  

Shear Behavior of Soft Rock Exposed to Alternate Dry and Wet under Constant Stress [PDF]

open access: yes, 2002
The surface of cutting rock slope has exposed to alternate dry and wet conditions for a long time, and they are weathered. We developed direct shear testing apparatus that can expose soft rock specimen to alternate dry and wet conditions under constant ...
Katae Toshio   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Acoustic and physiological effects of the surroundings in rock cutting process [PDF]

open access: yes, 2010
A noise effect arising in the rock cutting process is gaining a large attention as to the identification and optimization of the cuttingprocess. The sense experience acquired during the experiments in the process of rotary rock drilling related to the ...
František Krepelka   +2 more
core  

A parametric study for the design of an optimized ultrasonic-percussive planetary drill tool [PDF]

open access: yes, 2016
Traditional rotary drilling for planetary rock sampling, in situ analysis, and sample return are challenging because the axial force and holding torque requirements are not necessarily compatible with lightweight spacecraft architectures in low-gravity ...
Harkness, Patrick   +4 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Study conical pick cutting performance and fatigue life in breaking rock plate process with numerical simulation

open access: yesScientific Reports
The fatigue life and cutting performance of conical pick is essential for the roadheader machine in the excavation engineering. In rock breaking process, the rock structural conditions has a certain influence on the rock breaking and rock damage with ...
Mingyan Wang
doaj   +1 more source

Fractal Characteristic of Rock Cutting Load Time Series

open access: yesDiscrete Dynamics in Nature and Society, 2014
A test-bed was developed to perform the rock cutting experiments under different cutting conditions. The fractal theory was adopted to investigate the fractal characteristic of cutting load time series and fragment size distribution in rock cutting.
Hongxiang Jiang   +3 more
doaj   +1 more source

Geologic considerations in underground coal mining system design [PDF]

open access: yes, 1981
Geologic characteristics of coal resources which may impact new extraction technologies are identified and described to aid system designers and planners in their task of designing advanced coal extraction systems for the central Appalachian region ...
Camilli, F. A.   +3 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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