Results 81 to 90 of about 2,680,418 (361)
Underground SpaceWhen tunnel boring machines (TBMs) excavate through jointed rock masses, the cutting efficiency is strongly affected by the shear strength of joints, the mechanism of which, however, remains poorly understood.
Bolong Liu +6 more
doaj +1 more source
Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing
Advanced Science, EarlyView.This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang +10 more
wiley +1 more source
Anisotropic Mechanical Properties of Excavated Layered Rock Mass Considering the Joint Roughness
, 2023 Cao Liu +4 more
openalex +1 more source
Advanced Science, EarlyView.Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He +10 more
wiley +1 more source
Back-Analysis of Parameters of Jointed Surrounding Rock of Metro Station Based on Random Forest Algorithm Optimized by Cuckoo Search Algorithm [PDF]
, 2022 Xinping Guo, Annan Jiang, Xiang Liu
openalex +1 more source
Control of rock joint parameters on deformation of tunnel opening
, 2016 Tunneling in complex rock mass conditions is a challenging task, especially in the Himalayan terrain, where a number of unpredicted conditions are reported.
S. Panthee +3 more
semanticscholar +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang +6 more
wiley +1 more source
Effect of Joint Morphology on Fracture Behavior for Rock Mass: DEM Investigation on a Single Joint
EngThis study proposes a novel discrete element modelling (DEM) framework for investigating the fracture behavior of jointed rock masses, with particular emphasis on rock specimens containing a single pre-existing joint.
Chong Wang +5 more
doaj +1 more source