Results 31 to 40 of about 25,017 (258)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Research on buckling failure and anchorage parameters of slab-rent structure rock bedding slopes in Tianchi Energy South Open-pit Coal Mine

Meikuang Anquan, 2022
In this paper, according to the characteristics of bedding slope deformation and buckling failure of slab cracked rock mass in Xinjiang Tianchi Energy South open-pit Coal Mine, with the help of slope radar monitoring means, by transforming the prediction
LI Ming, DONG Mengmeng, WANG Aiwu, MA Xiyan   +3 more
doaj   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Stability Analysis of Soil and Rock Mixed Slope Based on Random Heterogeneous Structure

Advances in Civil Engineering
Due to the complexity in the heterogeneous internal structure and interactions between rocks and soil, the slide of soil–rock mixed slope is usually more complex than that of a homogeneous soil slope.
Yafei Wang, Zhanrong Zhang, Xingpei Kang, Hao Xie, Chenchen Wang, Kun Liu   +5 more
doaj   +1 more source

Study on the collapse mechanism of slopes containing weak interlayers due to rising water level

Results in Engineering
The centrifuge experiment was conducted to investigate the impact of weak interlayer reservoir bank slope water level rise on slope stability. The analysis of the experimental data revealed that the collapse of the reservoir bank slope was primarily ...
Lei Ma, Chao Zhang, Changkun Ma, Xueqiao Han   +3 more
doaj   +1 more source

Multimodal Data‐Driven Microstructure Characterization

Advanced Engineering Materials, EarlyView.
A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang, Santiago Benito, Özge Özgün, Sebastian Weber, Markus Stricker   +4 more
wiley   +1 more source

Relationship between the Groundwater Fluctuation and Deformation Behavior of Rock Slope at Mt. Buko

Journal of MMIJ, 2018
In the present study, the relation between groundwater fluctuations on a rock slope and the dis-placement of the Mt. Buko rock slope is analyzed. In general, the strength of a rock mass behavior is subject to the influence of water.
Megumi KONDO, Noriyoshi OZAWA, Hideo AOYAMA, Kazufumi YANO   +3 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

The stability issue of fractured rock mass slope under the influences of freeze–thaw cycle

Scientific Reports
Freeze–thaw failure of frozen rock slope often occurs during engineering construction and mining in cold area, which poses a great threat to engineering construction and people's life safety.
Naifei Liu, Yinliang Yang, Ning Li, Shihao Liang, Hua Liu, Cheng Li   +5 more
doaj   +1 more source

Paraglacial Rock Slope Stability Under Changing Environmental Conditions, Safuna Lakes, Cordillera Blanca Peru

Frontiers in Earth Science, 2021
Landslides or landslide-induced impact waves in high mountain lakes represent a high hazard for society, calling for realistic assessments of rock slope stability responsible for the process chain initiation.
Jan Klimeš, Jan Novotný, Alejo Cochacin Rapre, Jan Balek, Pavel Zahradníček, Pavel Zahradníček, Tazio Strozzi, Hamid Sana, Holger Frey, Miloš René, Petr Štěpánek, Petr Štěpánek, Jan Meitner, Johan Junghardt   +13 more
doaj   +1 more source