Syntaxin 3B Mediates Light‐Dependent Interactions with STXBP1 and Arrestin 4: Distinct Roles in Rods and Cones [PDF]
Advanced ScienceSyntaxin 3 (STX3), a member of the soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) family, plays a central role in vesicle fusion.
Lars Tebbe +5 more
doaj +3 more sources
BMC Genomics, 2003 Background The vertebrate opsins are proteins which utilise a retinaldehyde chromophore in their photosensory or photoisomerase roles in the visual/irradiance detection cycle.
Foster Russell G +2 more
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Retinal cone photoreceptors of the deer mouse Peromyscus maniculatus: development, topography, opsin expression and spectral tuning. [PDF]
PLoS ONE, 2013 A quantitative analysis of photoreceptor properties was performed in the retina of the nocturnal deer mouse, Peromyscus maniculatus, using pigmented (wildtype) and albino animals.
Patrick Arbogast +2 more
doaj +4 more sources
Discovery and design of photocyclic animal opsins: potential application to gene therapy from non-visual opsin research [PDF]
Eye and VisionOpsins are universal photoreceptive proteins in animals. Rhodopsin is the best-studied opsin and functions as a visual sensor in rod cells of human and mouse retinas.
Takahiro Yamashita
doaj +2 more sources
From pineal photoreception to optogenetics: functional colour opponency based on a pineal bistable opsin [PDF]
Eye and VisionMost animals sense light through opsins, which are photosensitive G protein–coupled receptors that utilize light information to regulate various physiological functions. In vertebrates, a representative example of such functions is vision, which is based
Seiji Wada +3 more
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Visual responses in mice lacking critical components of all known retinal phototransduction cascades. [PDF]
PLoS ONE, 2010 The mammalian visual system relies upon light detection by outer-retinal rod/cone photoreceptors and melanopsin-expressing retinal ganglion cells. Gnat1(-/-);Cnga3(-/-);Opn4(-/-) mice lack critical elements of each of these photoreceptive mechanisms via ...
Annette E Allen +4 more
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Ciliary Defects in Inherited Retinal Diseases. [PDF]
Adv Genet (Hoboken)The photoreceptor cilium is a specialized sensory organelle essential for vision. This review systematically summarizes the structural and functional defects of the cilium that lead to inherited retinal diseases (IRDs). It highlights key pathogenic genes, elucidates molecular mechanisms of degeneration, and evaluates emerging therapeutic strategies ...
Guo G, Li L, Zhou J, Ran J.
europepmc +2 more sources
Light intensity and opsin sensitivity shape the morphology of cone photoreceptor outer segments. [PDF]
PLoS BiologyRegulation of neural cell morphology remains a fundamental question in neuroscience. Photoreceptor cells, a specialized class of neurons capable of initiating the phototransduction cascade, exhibit distinct structural and morphological characteristics ...
Jingjin Xu +8 more
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Two genes, one culprit - a functional candidate validation of a SPATA7 deletion in dogs with day blindness/retinal degeneration. [PDF]
PLoS GeneticsInherited retinal diseases (IRDs) are a diverse group of disorders that share common vision deficits ranging from early onset blindness to severe and progressive later-onset disease. We report a form of early-onset day-vision loss, cone-rod dystrophy, in
Leonardo Murgiano +13 more
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Genomic organization of duplicated short wave-sensitive and long wave-sensitive opsin genes in the green swordtail,
BMC Evolutionary Biology, 2010 Background Long wave-sensitive (LWS) opsin genes have undergone multiple lineage-specific duplication events throughout the evolution of teleost fishes. LWS repertoire expansions in live-bearing fishes (family Poeciliidae) have equipped multiple species ...
Davidson William S +4 more
doaj +3 more sources