Predicting peak spectral sensitivities of vertebrate cone visual pigments using atomistic molecular simulations. [PDF]
PLoS Computational Biology, 2018 Vision is the dominant sensory modality in many organisms for foraging, predator avoidance, and social behaviors including mate selection. Vertebrate visual perception is initiated when light strikes rod and cone photoreceptors within the neural retina ...
Jagdish Suresh Patel +3 more
doaj +1 more source
Activation of mislocalized opsin kills rod cells: A novel mechanism for rod cell death in retinal disease [PDF]
Proceedings of the National Academy of Sciences, 2002 Rod photoreceptors are highly compartmentalized sensory neurons that maintain strict ultrastructural and molecular polarity. Structural subdivisions include the outer segment, inner segment, cell body, and synaptic terminal. The visual pigment rhodopsin is found predominantly in membranes of the rod cell outer segment but becomes mislocalized ...
Peter D, Alfinito +1 more
openaire +2 more sources
RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. [PDF]
, 2015 A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Berson, David M +8 more
core +2 more sources
Long-wavelength sensitive visual pigments of the guppy (): six opsins expressed in a single individual [PDF]
, 2007 Background The diversity of visual systems in fish has long been of interest for evolutionary biologists and neurophysiologists, and has recently begun to attract the attention of molecular evolutionary geneticists. Several recent studies
Chang, Belinda S, Weadick, Cameron J
core +2 more sources
The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic [PDF]
, 2012 Purpose. To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations. Methods. Eleven subjects were recruited, eight of whom have been previously described.
Banin, Eyal +19 more
core +2 more sources
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. [PDF]
PLoS Genetics, 2018 We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a presumptive intracellular chloride channel highly expressed in the retina, associated with autosomal recessive retinitis pigmentosa (arRP) in eight consanguineous ...
Lin Li +40 more
doaj +1 more source
Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses [PDF]
, 2016 Retinitis pigmentosa is a progressive retinal dystrophy that causes irreversible visual impairment and blindness. Retinal prostheses currently represent the only clinically available vision-restoring treatment, but the quality of vision returned remains ...
Barrett, John Martin +2 more
core +1 more source
Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish. [PDF]
PLoS Genetics, 2016 The visual system of a particular species is highly adapted to convey detailed ecological and behavioral information essential for survival. The consequences of structural mutations of opsins upon spectral sensitivity and environmental adaptation have ...
Mailin Sotolongo-Lopez +4 more
doaj +1 more source
Human Molecular Genetics, 2022 ABSTRACTThe correct expression of folded, functional rhodopsin (Rho) is critical for visual perception. However, this seven-transmembrane helical G protein-coupled receptor (GPCR) is prone to mutations with pathological consequences of retinal degeneration in retinitis pigmentosa (RP) due to Rho misfolding. Pharmacological chaperones that stabilize the
Joseph T Ortega +5 more
openaire +2 more sources
Spatiotemporal control of genome engineering in cone photoreceptors
Cell & Bioscience, 2023 Background Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to developing therapies for retinal diseases ...
Nan-Kai Wang +12 more
doaj +1 more source