Results 21 to 30 of about 6,500 (214)
Light-dependent Activation of Rod Transducin by Pineal Opsin [PDF]
Journal of Biological Chemistry, 1998 The pineal gland expresses a unique member of the opsin family (P-opsin; Max, M., McKinnon, P. J., Seidenman, K. J., Barrett, R. K., Applebury, M. L., Takahashi, J. S., and Margolskee, R. F. (1995) Science 267, 1502-1506) that may play a role in circadian entrainment and photo-regulation of melatonin synthesis. To study the function of this protein, an
M, Max +4 more
openaire +2 more sources
Activation of Transducin by Bistable Pigment Parapinopsin in the Pineal Organ of Lower Vertebrates. [PDF]
PLoS ONE, 2015 Pineal organs of lower vertebrates contain several kinds of photosensitive molecules, opsins that are suggested to be involved in different light-regulated physiological functions. We previously reported that parapinopsin is an ultraviolet (UV)-sensitive
Emi Kawano-Yamashita +5 more
doaj +1 more source
Restoration of vision with ectopic expression of human rod opsin [PDF]
The Lancet, 2015 Many retinal dystrophies result in photoreceptor loss, but the inner retinal neurons can survive, making them potentially amenable to emerging optogenetic therapies. Here, we show that ectopically expressed human rod opsin, driven by either a non-selective or ON-bipolar cell-specific promoter, can function outside native photoreceptors and restore ...
Jasmina Cehajic-Kapetanovic +8 more
openaire +2 more sources
Cell Death and Disease, 2022 Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal degeneration in humans. However, the pathogenesis remains largely unknown. There are two homologous genes of TULP1 in zebrafish, namely tulp1a and tulp1b.
Danna Jia +16 more
doaj +1 more source
Bat eyes have ultraviolet-sensitive cone photoreceptors. [PDF]
PLoS ONE, 2009 Mammalian retinae have rod photoreceptors for night vision and cone photoreceptors for daylight and colour vision. For colour discrimination, most mammals possess two cone populations with two visual pigments (opsins) that have absorption maxima at short
Brigitte Müller +5 more
doaj +1 more source
Calcium‐activated Opsin Phosphatase Activity in Retinal Rod Outer Segments [PDF]
European Journal of Biochemistry, 1996 We describe the presence in bovine retinal rod outer segments of a phosphatase which dephosphorylates phosphoopsin with an efficiency similar to that of PP2A, and which is stimulated by submicromolar levels of Ca2+ (half‐maximal activation, 0.4–0.5 μM). This enzyme is designated Ca2+‐activated opsin phosphatase (CAOP).
M A, Kutuzov, N, Bennett
openaire +2 more sources
BMC Biology, 2018 Background Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells.
Edward R. Ballister +3 more
doaj +1 more source
Retinoids in the visual cycle: role of the retinal G protein-coupled receptor
Journal of Lipid Research, 2021 Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration.
Elliot H. Choi +4 more
doaj +1 more source
BiP prevents rod opsin aggregation
Molecular Biology of the Cell, 2012 Mutations in rod opsin—the light-sensitive protein of rod cells—cause retinitis pigmentosa. Many rod opsin mutations lead to protein misfolding, and therefore it is important to understand the role of molecular chaperones in rod opsin biogenesis. We show that BiP (HSPA5) prevents the aggregation of rod opsin.
Athanasiou, D. +7 more
openaire +3 more sources
Evolution of the eyes of vipers with and without infrared-sensing pit organs [PDF]
, 2019 We examined lens and brille transmittance, photoreceptors, visual pigments, and visual opsin gene sequences of viperid snakes with and without infrared-sensing pit organs. Ocular media transmittance is high in both groups.
Douglas, R. H. +12 more
core +3 more sources