Results 61 to 70 of about 6,500 (214)
The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control [PDF]
Human Molecular Genetics, 2014 Mutations in rhodopsin, the light-sensitive protein of rod cells, are the most common cause of autosomal dominant retinitis pigmentosa (ADRP). Many rod opsin mutations, such as P23H, lead to misfolding of rod opsin with detrimental effects on photoreceptor function and viability.
Athanasiou, D +7 more
openaire +4 more sources
Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors [PDF]
, 2017 Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous organelles involved in transduction of environmental signals such as light sensation in photoreceptors.
Bachmann-Gagescu, Ruxandra +7 more
core +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation [PDF]
, 2002 Mutations in the photopigment rhodopsin are the major cause of autosomal dominant retinitis pigmentosa. The majority of mutations in rhodopsin lead to misfolding of the protein.
Cheetham, ME +3 more
core
Colour Vision Deficiency in Health Professions Education: A Narrative Literature Review
The Clinical Teacher, Volume 23, Issue 3, June 2026.ABSTRACT Background Colour vision deficiency (CVD) or colour blindness can affect healthcare professionals in tasks that require colour perception. Despite its occurrence, there is limited awareness within healthcare education to support students and practitioners with CVD.
Marnie Imhoff +3 more
wiley +1 more source
A second type of rod opsin cDNA from the common carp (Cyprinus carpio) [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1997 A second type of rhodopsin cDNA from carp (cRh-II) shared 97.2% polynucleotide identity with the previously reported cRh-I. The deduced amino acid sequences of cRh-I and cRh-II exhibited 98.6% identity. The key difference between these two types of cRh is that valine at position 169 of cRh-I was replaced by glutamic acid in cRh-II.
J, Lim, J L, Chang, H J, Tsai
openaire +2 more sources
PLoS ONE, 2020 To convert external light into internal neural signal, vertebrates rely on a special group of proteins, the visual opsins. Four of the five types of visual opsins-short-wavelength sensitive 1 (Sws1), short-wavelength sensitive 2 (Sws2), medium-wavelength
Chia-Hao Chang +3 more
doaj +1 more source
Zebrafish differentially process colour across visual space to match natural scenes [PDF]
, 2018 Animal eyes have evolved to process behaviourally important visual information, but how retinas deal with statistical asymmetries in visual space remains poorly understood.
Baden, Thomas +6 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Mechanisms of wavelength tuning in the rod opsins of deep-sea fishes
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1997 The main object of this study was to investigate the molecular basis for changes in the spectral sensitivity of the visual pigments of deep-sea fishes. The four teleost species studied, Hoplostethus mediterraneus, Cataetyx laticeps, Gonostoma elongatum and Histiobranchus bathybius, are phylogenetically distant from each other and live at depths ranging
Hope, AJ +3 more
openaire +3 more sources