Results 231 to 240 of about 341,043 (301)

Metatranscriptomics profiling reveals rodent- and shrew-borne viral diversity and evolutionary relationships in Guangzhou, China. [PDF]

Virol Sin
Chen S, Li W, Fan L, Xu C, Liu S, Li H, Liu P, Zhu W, Wu X, Qin P, Li J, Ma X, Wei Y.   +12 more
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

<i>Acomys cahirinus seurati</i> as a Potential Reservoir Host of <i>Leishmania major</i>. [PDF]

Pathogens
Karlin S, Bečvářová B, Benallal KE, Bečvář T, Mezai G, Zaabar M, Mefissel M, Volf P, Sádlová J.   +8 more
europepmc   +1 more source

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source

Virome diversity and zoonotic risks of rodents along ecological gradients in the Northern Tianshan Mountains, China. [PDF]

Microbiome
Du H, Zhang L, Wang W, Chang Y, Zhang C, Xiang H, Men Y, Sun H, Wen H, Yun F, Zhang X, Zheng K, Zhang L, Zhu Y, Bi Y, Ma Z.   +15 more
europepmc   +1 more source

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

Animal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li, Fansen Lin, Hongzhi Gao, Yun Zhao, Yuqi Liu   +4 more
wiley   +1 more source

Transcriptomic validation of a 7,12 Dimethylbenz(a)anthracene (DMBA)‐induced leukemia rat model: Parallels with human leukemogenesis

Animal Models and Experimental Medicine, EarlyView.
7,12‐Dimethylbenz[a]anthracene (DMBA) could induce leukemia and other types of cancers in rat models. Transcriptomics revealed gene expression profile that parallels with human leukemia. DMBA‐induced differential gene expression could validate the developed rat model.
Khaldoon Alsamman, Omar S. El‐Masry
wiley   +1 more source

The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Alzheimer's and Parkinson's disease: a systematic review and meta-analysis. [PDF]

Front Aging Neurosci
Ferreira AFF, Santos-Silva AC, Muratori BG, Britto LR.   +3 more
europepmc   +1 more source

Rodent models of Alzheimer’s disease [PDF]

, 2019
openaire   +1 more source