Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?
Clinical Pharmacology &Therapeutics, EarlyView.Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart +6 more
wiley +1 more source
Could the naked mole-rat become the new standard for studying human gut health and probiotics?<sup>†</sup>. [PDF]
J PatholPearson AC +2 more
europepmc +1 more source
PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature
Clinical Pharmacology &Therapeutics, EarlyView.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory +13 more
wiley +1 more source
Preclinical animal models for onchocerciasis and loiasis: A systematic review of applications in drug screening. [PDF]
PLoS Negl Trop DisAyiseh RB +4 more
europepmc +1 more source
Andes hantavirus - A primer. [PDF]
Npj VirusesHalwe NJ, Tscherne A, Krammer F.
europepmc +1 more source
Neural network modeling of Lassa fever spread and disability effects. [PDF]
Sci RepSabir Z +6 more
europepmc +1 more source
Hanta on the Hondius - public health and bioethical perspectives of the recent <i>Andes</i> hantavirus cruise ship outbreak. [PDF]
New Microbes New InfectTsiodras S +10 more
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Infectome Landscape of Rodents and Shrews in Guangdong Province Reveals Diverse Pathogens with Zoonotic Potential in Wildlife. [PDF]
VirusesLin Y +13 more
europepmc +1 more source