Results 51 to 60 of about 2,506,343 (333)

A Calibrated Method of Massage Therapy Decreases Systolic Blood Pressure Concomitant With Changes in Heart Rate Variability in Male Rats. [PDF]

, 2017
ObjectiveThe purpose of this study was to develop a method for applying calibrated manual massage pressures by using commonly available, inexpensive sphygmomanometer parts and validate the use of this approach as a quantitative method of applying massage
Curras-Collazo, Margarita C, Dobyns, Abigail, Gutierrez, Roberto, Jha, Vidyasagar, Kaprelian, Anthony, Spurgin, Kurt A, Wilson, Christopher G, Xu, Karen H   +7 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Total orthotopic small bowel transplantation in swine under FK 506 [PDF]

, 1994
Previous experimental studies in rodents and in dogs have established the efficacy of FK 506 in controlling the immunologic events following small bowel or multivisceral transplantation.1–5 To complete the assessment of FK 506 in experimental small bowel
Alessiani, M, Arbustini, E, De Ponti, F, Dionigi, P, Grossi, P, Ippoliti, GB, Maestri, M, Moratti, R, Noli, S, Regazzi, M, Spada, M, Starzl, TE, Todo, S, Vischi, S, Zonta, A   +14 more
core  

Risk factors for human acute leptospirosis in northern Tanzania [PDF]

, 2018
Introduction: Leptospirosis is a major cause of febrile illness in Africa but little is known about risk factors for human infection. We conducted a cross-sectional study to investigate risk factors for acute leptospirosis and Leptospira ...
Allan, Kathryn J., Biggs, Holly M., Cash-Goldwasser, Shama, Cleaveland, Sarah, Crump, John A., Galloway, Renee L., Halliday, Jo E.B., Kazwala, Rudovick R., Lwezaula, Bingileki F., Maro, Venance P., Maze, Michael J., Mmbaga, Blandina T., Muiruri, Charles, Rubach, Matthew P., Saganda, Wilbrod, Shand, Michael C., Sharples, Katrina J.   +16 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Two predominant MUPs, OBP3 and MUP13, are male pheromones in rats

Frontiers in Zoology, 2018
Background In rats, urine-borne male pheromones comprise organic volatile compounds and major urinary proteins (MUPs). A number of volatile pheromones have been reported, but no MUP pheromones have been identified in rat urine.
Xiao Guo, Huifen Guo, Lei Zhao, Yao-Hua Zhang, Jian-Xu Zhang   +4 more
doaj   +1 more source

Presence of Salmonella and Campylobacter spp. in Wild Small Mammals on Organic Farms [PDF]

, 2005
The presence of Salmonella and Campylobacter spp. in rodents and insectivores (n 282) was investigated on organic farms. Infections were encountered in house mice (8 of 83 Campylobacter positive and 1 of 83 Salmonella sp.
B. G., Meerburg, W. F., Jacobs-Reitsma
core  

Dispersal and population structure at different spatial scales in the subterranean rodent Ctenomys australis [PDF]

, 2010
This study was funded by grants from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP5838), Agencia de Promoción Científica y Tecnológica de la Argentina (PICTO1-423, BID-1728/OC-AR), and the programme ECOS-Sud France/Argentina ...
Gaggiotti, Oscar E., Kittlein, Marcelo J., Lessa, Enrique P., Mapelli, Fernando J., Mora, Matias S.   +4 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

BMC Biotechnology, 2018
Background The CRISPR/Cas9 system has been widely used to generate gene knockout/knockin models by inducing frameshift mutants in cell lines and organisms.
Dafeng Chen, Ji-Xin Tang, Beibei Li, Li Hou, Xianhui Wang, Le Kang   +5 more
doaj   +1 more source