Results 171 to 180 of about 5,045,501 (353)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
In Madagascar religions play a key role in peace and conflict processes [PDF]
, 2020 Élise Féron +1 more
openalex
Entrepreneurial Activity and Civil War in Colombia: Exploring the Mutual Determinants between Armed Conflict and the Private Sector [PDF]
TAs elsewhere, the Colombian private sector has been accused of promoting or profiting from violence in the country. However, the private sector’s role in the armed conflict and the impact of conflict on entrepreneurial activity vary, as reflected by ...
Leiteritz, Ralf +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Effect of Psychological Capital and Role Conflict on the Academic Entrepreneurial Intents of Chinese Teachers in Higher Education: A Study Based on the Theory of Planned Behavior. [PDF]
Front Psychol, 2022 Liao K, Liu Z, Li B.
europepmc +1 more source
Kofi Annan - UN secretary-general and his role in resolving international conflicts [PDF]
Tatiana Durisova
openalex +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The role conflict-burnout-depression link among Chinese female health care and social service providers: the moderating effect of marriage and motherhood. [PDF]
BMC Public Health, 2022 Zheng G, Lyu X, Pan L, Chen A.
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Revista Cubana de Salud y TrabajoIntroducción: En el Conflicto Trabajo-Familia aparecen exigencias laborales incompatibles con actividades del rol familiar, puede presentarse en tres formas: conflicto basado en tiempo, en comportamiento y en tensión generada; esto dos direcciones ...
Emilia Nohemi Cervantes Zambrano +3 more
doaj