The role conflict-burnout-depression link among Chinese female health care and social service providers: the moderating effect of marriage and motherhood. [PDF]
BMC Public Health, 2022 Zheng G, Lyu X, Pan L, Chen A.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Burnout and inter-role conflict in telework: a gendered resource erosion pathway via job crafting. [PDF]
Front PsycholYeves J +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The path mechanism of occupational burnout affecting the health of emergency nurses: a moderated mediation model of work-family behavior role conflict and the work environment. [PDF]
Front Public HealthChen C +6 more
europepmc +1 more source
Measuring Gender Role Conflict, Internalized Stigma, and Racial and Sexual Identity in Behaviorally Bisexual Black Men. [PDF]
Arch Sex Behav, 2022 Del Pino HE +5 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Engaging Civil Society in the Nagorno Karabakh Conflict: What Role for the EU and its Neighbourhood Policy? [PDF]
The conflict over Nagorno Karabakh, opposing Armenia and Azerbaijan, is the longest conflict in the OSCE area and a fundamental security threat to the South Caucasus and surrounding regions, preventing full and inclusive economic development and ...
Licínia Simão
core
Impact of role conflict and job stress on turnover intention among Korean physician assistant nurses: A cross-sectional study. [PDF]
Int J Nurs SciLee JW, Choi EH, Back JS.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source