Results 71 to 80 of about 1,984,500 (256)

Leading from afar, losing from within: how and when laissez-faire leadership fuels quiet quitting behaviours of employees

open access: yesCogent Business & Management
This study investigates the influence of laissez-faire leadership on employee quiet quitting behaviours. Drawing on the Job Demands–Resources theory and the Stressor-Detachment model, it examines how laissez-faire leadership affects quiet quitting ...
Erasmus Keli Swanzy   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

DAMPAK KONFLIK PERAN TERHADAP STRES DAN KEPUASAN KERJA KARYAWAN PT. JOMBANG INTERMEDIA PRESS (JAWA POS RADAR JOMBANG)

open access: yesJurnal Manajemen Indonesia, 2018
The purpose of this research is to know the effect of role conflict on employee job satisfaction with job stress as a mediation variable at PT. Jombang Intermedia Press (Jawa Pos Radar Jombang).
Kristin Juwita , Devy Arintika
doaj   +1 more source

Role of oxidative stress in endometriosis

open access: yesReproductive BioMedicine Online, 2006
Endometriosis is a chronic pleomorphic disorder with pelvic or systemic manifestations, and is characterized by the presence of endometrial glands and stroma. In the United States, the prevalence of the disease is estimated to range from 2 to 50% in women of reproductive age.
Sajal, Gupta   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nursing Teachers’ Perception of Role Strain: A Qualitative Study

open access: yesJournal of Research Development in Nursing and Midwifery, 2015
Background and Objective: Role Strain refers to the felt difficulty in fulfilling expectations, complying with the role obligations and balancing the various dimensions of roles. Role strain is a subjective state of distress experienced.
Shohreh Kolagari   +4 more
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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