Results 91 to 100 of about 438,665 (263)

Root surface caries [PDF]

British Dental Journal, 2013
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The AUX1-AFB1-CNGC14 module establishes a longitudinal root surface pH profile. [PDF]

Elife, 2023
Serre NBC, Wernerová D, Vittal P, Dubey SM, Medvecká E, Jelínková A, Petrášek J, Grossmann G, Fendrych M.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Morphometric Measurements of Root Anatomic Areas of Maxillary First Premolar Teeth in a Representative Nepalese Population

Journal of College of Medical Sciences-Nepal
Background The prognosis of furcation involved maxillary first premolar is typically guarded to poor. The presence of concavities in the root trunk and the positioning of the roots in the buccal and palatal regions of the teeth are responsible for its ...
Nashib Pandey, Sushmit Koju, Rosina Bhattarai, Kanistika Jha, Merina Shakya, Prabash Roy, Rajib Chaulagain   +6 more
doaj   +1 more source

Fibroblast Viability Through Mechanical and Chemical Root Surface Modifications in Periodontal Healing: An In Vitro Comparative Study. [PDF]

Cureus, 2023
Felemban B.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Fine root morphological characteristics and biomass distribution characteristics of different artificial forests in coastal salt land and their influencing factors

Frontiers in Plant Science
To elucidate the ecological adaptations of fine root morphological traits and biomass in tree species with different life forms to coastal saline soil, five species (Robinia pseudoacacia(RP), Sapium sebiferum(SA), Salix matsudana(SM), Quercus virginiana ...
Zhibao Wang, Jing Liang, Hong Jiang, Xiangbin Gao, Shouchao Yu, Chuanjie Zhou, Yuwei Guo   +6 more
doaj   +1 more source

Efficacy of two diode lasers in the removal of calculus from the root surface: An in vitro study. [PDF]

Clin Exp Dent Res, 2023
Marcattili D, Mancini L, Tarallo F, Casalena F, Pietropaoli C, Marchetti E.   +5 more
europepmc   +1 more source