Results 111 to 120 of about 6,864,061 (305)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The Pd (100)-(root 5 x root 5)R27 degrees-O surface oxide: A LEED, DFT and STM study

, 2007
Using low energy electron diffraction (LEED), density functional theory (DFT) and scanning tunneling microscopy (STM), we have re-analyzed the Pd(100)-(root 5 x root 5)R27 degrees-O surface oxide structure consisting, in the most recent model, of a ...
Lundgren, Edvin, Kresse, G., Lundgren, Edvin,, Mikkelsen, Anders, Blum, V., Seriani, N., Mikkelsen, Anders,, Kostelník, P., Mikkelsen, A., Seriani, Nicola, Schmid, M., Sikola, T., Varga, P., Lundgren, E., Sikola, Tomas, Kresse, Georg, Lund University., Blum, Volker, Schmid, Michael, Varga, Peter, Kostelnik, Petr   +20 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Root system traits as key determinants of drought tolerance in safflower (Carthamus tinctorius L.) genotypes under stress conditions

Scientific Reports
Safflower (Carthamus tinctorius L.) is gaining recognition as a significant oilseed crop suitable for arid environments, attributed to its deep and extensive root system; nevertheless, the genetic foundation of its drought tolerance is still inadequately
Somayeh Soufinia, Reza Haghi, Arash Fazeli   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Effect of Plain and Fluoridated Milk on Root Surface Caries in Vitro

, 2007
The caries-protective effect of milk and fluoridated milk on enamel has been reported; however, few data are available concerning the role of milk and/or fluoridated milk on root surfaces.
M. M. Hogan, J. S. Wefel, R. Ivančaková, J. D. Harless   +3 more
core  

Morphological and Symbiotic Root Modifications for Mineral Acquisition from Nutrient-Poor Soils

, 2018
Plants have the ability to form vast root systems with lengths measuring up to several kilometers and branch roots numbering in millions. These expansive root systems provide plants with a large surface area for water and nutrient uptake from the ...
Gastón Muñoz, Benedito, V A, Mabel Delgado, Morcillo, R J L, P. Cornejo-Rivas, Cornejo-Rivas, P, Muñoz, Gaston, A. Zuniga-Feest, Delgado, Mabel, V. A. Benedito, A. Kleinert, Dames, Joanna F, Kleinert, Aleysia, R. J. L. Morcillo, Zuniga-Feest, A, J. Dames   +15 more
core   +1 more source

Root Penetration of Smeared Soil Surfaces

Experimental Agriculture, 1970
SUMMARYWinter wheat seeds were grown on compressed soil (a) with and without smearing, (b) with surface horizontal or at 45°, and (c) with and without a sand cover. Germination was not affected. At a soil suction of 0·1 bar, root penetration of the horizontal surface was decreased by smearing and by absence of an overburden; on a surface of 45 ...
openaire   +1 more source