Results 141 to 150 of about 119,438 (260)

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Root traits correlate with crop rhizosphere microbiome diversity independent of legume relatedness. [PDF]

ISME Commun
Stewart JD, Klein M, Jaupitre S, Oyarte-Galvez L, Dong L, Bouwmeester HJ, Kiers ET, Kokkoris V, Weedon JT, Weedon JT.   +9 more
europepmc   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Root traits and mycorrhizal fungi mediate reactive N and warming impacts on soil organic carbon. [PDF]

Nat Commun
Qiu Y, Zhao Y, Wang B, Xu X, He T, Zhang K, Bai T, Li Z, Ye C, Gillespie C, Wang X, Zhao Y, Guo L, Qian K, Chen H, Cao X, Wu S, Guo L, Tisdale R, Woodley A, Garcia K, Zhu W, Liu L, Wang Y, Zhang Y, Hu S.   +25 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Characterization of black oat root exudates in the presence of interspecific weed species and intraspecific neighbors, and their effects on root traits. [PDF]

Front Plant Sci
Eroğlu ÇG, Bennett AA, Steininger-Mairinger T, Hann S, Rueda Ayala VP, Wirth J, Gfeller A.   +6 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Rooting for function: community-level fine-root traits relate to many ecosystem functions. [PDF]

New Phytol
Barry KE, Hennecke J, Weigelt A, Bergmann J, Bruelheide H, Freschet GT, Iversen CM, Kuyper TW, Laughlin DC, McCormack ML, Roumet C, van der Plas F, van Ruijven J, Wijsmuller R, Auge H, Eisenhauer N, Haase J, Nock CA, Oelmann Y, Wilcke W, Mommer L.   +20 more
europepmc   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Relationships among leaf, stem, and root traits of <i>Pseudotsuga sinensis</i> under karst rocky desertification habitats, southwest China. [PDF]

Front Plant Sci
Li W, He F, Li L, Zou S, He B, Bai X, Yang Y.   +6 more
europepmc   +1 more source