Results 101 to 110 of about 509,537 (315)

Novel Insights into Botanical Seed Production of Xanthosoma spp. in Cuba

open access: yesAgronomy
Investigating diverse techniques for promoting flowering in Xanthosoma is crucial for managing sexual reproduction, producing authentic botanical seeds, and increasing Xanthosoma’s genetic diversity.
Alay Jiménez-Medina   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Evidence that Evidence Doesn't Matter: Human Trafficking Cases in Canada

open access: yesAtlantis, 2016
This article considers the ways in which the political pressures that have structured Canada’s involvement in the fight against human trafficking and the on-the-ground enforcement of laws adopted through Canada’s positioning as an anti-trafficking nation
Katrin Roots, Ann De Shalit
doaj  

Allocation Patterns and Strategies of Carbon, Nitrogen, and Phosphorus Densities in Three Typical Desert Plants

open access: yesPlants
The densities of carbon, nitrogen, and phosphorus (C-N-P) reflect the adaptation and response of desert plants to hyper-arid environments. However, the allocation strategies for biomass and C-N-P densities among various plant life forms remain poorly ...
Guangxing Zhao   +10 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Additional file 1 of Metabolic alterations provide insights into Stylosanthes roots responding to phosphorus deficiency

open access: green, 2020
Jiajia Luo   +7 more
openalex   +1 more source

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